Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media

Indazolone derivatives exhibit a wide range of biological and pharmaceutical properties. We report a rapid and efficient approach to provide structurally diverse 2-N-substituted indazolones via photochemical cyclization in aqueous media at room temperature. This straightforward protocol is halide co...

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Detalles Bibliográficos
Autores principales: Nie, Hui-Jun, Guo, An-Di, Lin, Hai-Xia, Chen, Xiao-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063774/
https://www.ncbi.nlm.nih.gov/pubmed/35520758
http://dx.doi.org/10.1039/c9ra02466b
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author Nie, Hui-Jun
Guo, An-Di
Lin, Hai-Xia
Chen, Xiao-Hua
author_facet Nie, Hui-Jun
Guo, An-Di
Lin, Hai-Xia
Chen, Xiao-Hua
author_sort Nie, Hui-Jun
collection PubMed
description Indazolone derivatives exhibit a wide range of biological and pharmaceutical properties. We report a rapid and efficient approach to provide structurally diverse 2-N-substituted indazolones via photochemical cyclization in aqueous media at room temperature. This straightforward protocol is halide compatible for the synthesis of halogenated indazolones bearing a broad scope of substrates, which suggests a new avenue of great importance to medicinal chemistry.
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spelling pubmed-90637742022-05-04 Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media Nie, Hui-Jun Guo, An-Di Lin, Hai-Xia Chen, Xiao-Hua RSC Adv Chemistry Indazolone derivatives exhibit a wide range of biological and pharmaceutical properties. We report a rapid and efficient approach to provide structurally diverse 2-N-substituted indazolones via photochemical cyclization in aqueous media at room temperature. This straightforward protocol is halide compatible for the synthesis of halogenated indazolones bearing a broad scope of substrates, which suggests a new avenue of great importance to medicinal chemistry. The Royal Society of Chemistry 2019-04-30 /pmc/articles/PMC9063774/ /pubmed/35520758 http://dx.doi.org/10.1039/c9ra02466b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Nie, Hui-Jun
Guo, An-Di
Lin, Hai-Xia
Chen, Xiao-Hua
Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
title Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
title_full Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
title_fullStr Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
title_full_unstemmed Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
title_short Rapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media
title_sort rapid and halide compatible synthesis of 2-n-substituted indazolone derivatives via photochemical cyclization in aqueous media
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063774/
https://www.ncbi.nlm.nih.gov/pubmed/35520758
http://dx.doi.org/10.1039/c9ra02466b
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