A novel method for PEGylation of chitosan nanoparticles through photopolymerization

An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized throu...

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Detalles Bibliográficos
Autores principales: Bozuyuk, Ugur, Gokulu, Ipek S., Dogan, Nihal Olcay, Kizilel, Seda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063996/
https://www.ncbi.nlm.nih.gov/pubmed/35519348
http://dx.doi.org/10.1039/c9ra00780f
Descripción
Sumario:An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized through altered PEG chain length, concentration and duration of UV exposure. The method developed here has potential for clinical translation of chitosan nanoparticles. It also allows for the scalable and fast synthesis of nanoparticles with colloidal stability.

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