A novel method for PEGylation of chitosan nanoparticles through photopolymerization

An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized throu...

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Detalles Bibliográficos
Autores principales: Bozuyuk, Ugur, Gokulu, Ipek S., Dogan, Nihal Olcay, Kizilel, Seda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063996/
https://www.ncbi.nlm.nih.gov/pubmed/35519348
http://dx.doi.org/10.1039/c9ra00780f
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author Bozuyuk, Ugur
Gokulu, Ipek S.
Dogan, Nihal Olcay
Kizilel, Seda
author_facet Bozuyuk, Ugur
Gokulu, Ipek S.
Dogan, Nihal Olcay
Kizilel, Seda
author_sort Bozuyuk, Ugur
collection PubMed
description An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized through altered PEG chain length, concentration and duration of UV exposure. The method developed here has potential for clinical translation of chitosan nanoparticles. It also allows for the scalable and fast synthesis of nanoparticles with colloidal stability.
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spelling pubmed-90639962022-05-04 A novel method for PEGylation of chitosan nanoparticles through photopolymerization Bozuyuk, Ugur Gokulu, Ipek S. Dogan, Nihal Olcay Kizilel, Seda RSC Adv Chemistry An ultrafast and convenient method for PEGylation of chitosan nanoparticles has been established through a photopolymerization reaction between the acrylate groups of PEG and methacrylated-chitosan nanoparticles. The nanoparticle characteristics under physiological pH conditions were optimized through altered PEG chain length, concentration and duration of UV exposure. The method developed here has potential for clinical translation of chitosan nanoparticles. It also allows for the scalable and fast synthesis of nanoparticles with colloidal stability. The Royal Society of Chemistry 2019-05-07 /pmc/articles/PMC9063996/ /pubmed/35519348 http://dx.doi.org/10.1039/c9ra00780f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Bozuyuk, Ugur
Gokulu, Ipek S.
Dogan, Nihal Olcay
Kizilel, Seda
A novel method for PEGylation of chitosan nanoparticles through photopolymerization
title A novel method for PEGylation of chitosan nanoparticles through photopolymerization
title_full A novel method for PEGylation of chitosan nanoparticles through photopolymerization
title_fullStr A novel method for PEGylation of chitosan nanoparticles through photopolymerization
title_full_unstemmed A novel method for PEGylation of chitosan nanoparticles through photopolymerization
title_short A novel method for PEGylation of chitosan nanoparticles through photopolymerization
title_sort novel method for pegylation of chitosan nanoparticles through photopolymerization
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063996/
https://www.ncbi.nlm.nih.gov/pubmed/35519348
http://dx.doi.org/10.1039/c9ra00780f
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