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Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research

The branches of the porcine subclavian artery are frequently used in endovascular stroke training and research. This study aimed to determine a porcine weight group, in which the arterial diameters most closely match human cerebral artery diameters, and thus optimize the porcine in-vivo model for ne...

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Autores principales: Mathern, Nathalie, Yousefian, Ehsan, Ridwan, Hani, Nikoubashman, Omid, Wiesmann, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064086/
https://www.ncbi.nlm.nih.gov/pubmed/35503785
http://dx.doi.org/10.1371/journal.pone.0268005
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author Mathern, Nathalie
Yousefian, Ehsan
Ridwan, Hani
Nikoubashman, Omid
Wiesmann, Martin
author_facet Mathern, Nathalie
Yousefian, Ehsan
Ridwan, Hani
Nikoubashman, Omid
Wiesmann, Martin
author_sort Mathern, Nathalie
collection PubMed
description The branches of the porcine subclavian artery are frequently used in endovascular stroke training and research. This study aimed to determine a porcine weight group, in which the arterial diameters most closely match human cerebral artery diameters, and thus optimize the porcine in-vivo model for neuroendovascular purposes. A group of 42 German Landrace swine (45–74 kg) was divided into four subgroups according to their weight. Angiographic images of the swine were used to determine the arterial diameter of the main branches of the subclavian artery: axillary artery, brachial artery, external thoracic artery, subscapular artery (at two different segments), suprascapular artery, caudal circumflex humeral artery, thoracodorsal artery, and circumflex scapular artery. The porcine arterial diameters were correlated with animal weight and compared to luminal diameters of human arteries which are commonly involved in stroke: internal carotid artery, basilar artery, vertebral artery, middle cerebral artery and M2 branches of the middle cerebral artery. Swine weight was positively correlated with porcine arterial diameter. The most conformity with human arterial diameters was found within the two heavier porcine groups (55–74 kg). We suggest the use of swine with a weight between 55–59.7 kg, as lighter animals show less similarity with human arterial diameters and heavier animals could cause more problems with manipulation and handling.
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spelling pubmed-90640862022-05-04 Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research Mathern, Nathalie Yousefian, Ehsan Ridwan, Hani Nikoubashman, Omid Wiesmann, Martin PLoS One Research Article The branches of the porcine subclavian artery are frequently used in endovascular stroke training and research. This study aimed to determine a porcine weight group, in which the arterial diameters most closely match human cerebral artery diameters, and thus optimize the porcine in-vivo model for neuroendovascular purposes. A group of 42 German Landrace swine (45–74 kg) was divided into four subgroups according to their weight. Angiographic images of the swine were used to determine the arterial diameter of the main branches of the subclavian artery: axillary artery, brachial artery, external thoracic artery, subscapular artery (at two different segments), suprascapular artery, caudal circumflex humeral artery, thoracodorsal artery, and circumflex scapular artery. The porcine arterial diameters were correlated with animal weight and compared to luminal diameters of human arteries which are commonly involved in stroke: internal carotid artery, basilar artery, vertebral artery, middle cerebral artery and M2 branches of the middle cerebral artery. Swine weight was positively correlated with porcine arterial diameter. The most conformity with human arterial diameters was found within the two heavier porcine groups (55–74 kg). We suggest the use of swine with a weight between 55–59.7 kg, as lighter animals show less similarity with human arterial diameters and heavier animals could cause more problems with manipulation and handling. Public Library of Science 2022-05-03 /pmc/articles/PMC9064086/ /pubmed/35503785 http://dx.doi.org/10.1371/journal.pone.0268005 Text en © 2022 Mathern et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mathern, Nathalie
Yousefian, Ehsan
Ridwan, Hani
Nikoubashman, Omid
Wiesmann, Martin
Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research
title Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research
title_full Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research
title_fullStr Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research
title_full_unstemmed Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research
title_short Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research
title_sort comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064086/
https://www.ncbi.nlm.nih.gov/pubmed/35503785
http://dx.doi.org/10.1371/journal.pone.0268005
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