Th17 cell plasticity towards a T-bet-dependent Th1 phenotype is required for bacterial control in Staphylococcus aureus infection

Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a major health burden worldwide. CD4(+) T helper cells are involved in the immune response to S. aureus by supporting antibody production and phagocytosis. In particular, Th1 and Th17 cells secreting IFN-γ and I...

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Detalles Bibliográficos
Autores principales: Bartsch, Patricia, Kilian, Christoph, Hellmig, Malte, Paust, Hans-Joachim, Borchers, Alina, Sivayoganathan, Amirrtavarshni, Enk, Leon, Zhao, Yu, Shaikh, Nikhat, Büttner, Henning, Wong, Milagros N., Puelles, Victor G., Wiech, Thorsten, Flavell, Richard, Huber, Tobias B., Turner, Jan-Eric, Bonn, Stefan, Huber, Samuel, Gagliani, Nicola, Mittrücker, Hans-Willi, Rohde, Holger, Panzer, Ulf, Krebs, Christian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064098/
https://www.ncbi.nlm.nih.gov/pubmed/35446923
http://dx.doi.org/10.1371/journal.ppat.1010430

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