Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells

Drug-induced liver injury is one of the main causes of drug non-approval and drug withdrawal by the Food and Drug Administration (FDA). Acetaminophen (APAP) is a widely used non-steroidal anti-inflammatory drug for treating fever and headache. APAP is considered safe at therapeutic doses; however, t...

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Detalles Bibliográficos
Autores principales: Wang, Shan, Tian, Yu, Lu, Shan, Wang, Ruiying, Shang, Hai, Zhang, Xuelian, Zhang, Chenyang, Sun, Guibo, Xu, Xudong, Sun, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064191/
https://www.ncbi.nlm.nih.gov/pubmed/35514855
http://dx.doi.org/10.1039/c9ra00483a

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