Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose

A fluorescent derivative of trehalose with two dansyl groups (DAT) has been synthesized. It is characterised by a large Stokes shift, good permeability in human living cells and a well detectable fluorescent signal within the cells. Notably, in intestinal cells DAT is sequestered in vesicles induced...

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Detalles Bibliográficos
Autores principales: Locatelli, Alessandra, Iommarini, Luisa, Graziadio, Alessandra, Leoni, Alberto, Porcelli, Anna Maria, Iotti, Stefano, Malucelli, Emil, Francia, Francesco, Venturoli, Giovanni, Farruggia, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064201/
https://www.ncbi.nlm.nih.gov/pubmed/35514834
http://dx.doi.org/10.1039/c9ra01800j
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author Locatelli, Alessandra
Iommarini, Luisa
Graziadio, Alessandra
Leoni, Alberto
Porcelli, Anna Maria
Iotti, Stefano
Malucelli, Emil
Francia, Francesco
Venturoli, Giovanni
Farruggia, Giovanna
author_facet Locatelli, Alessandra
Iommarini, Luisa
Graziadio, Alessandra
Leoni, Alberto
Porcelli, Anna Maria
Iotti, Stefano
Malucelli, Emil
Francia, Francesco
Venturoli, Giovanni
Farruggia, Giovanna
author_sort Locatelli, Alessandra
collection PubMed
description A fluorescent derivative of trehalose with two dansyl groups (DAT) has been synthesized. It is characterised by a large Stokes shift, good permeability in human living cells and a well detectable fluorescent signal within the cells. Notably, in intestinal cells DAT is sequestered in vesicles induced by trehalose pre-treatment and colocalizes with lipid droplets.
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spelling pubmed-90642012022-05-04 Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose Locatelli, Alessandra Iommarini, Luisa Graziadio, Alessandra Leoni, Alberto Porcelli, Anna Maria Iotti, Stefano Malucelli, Emil Francia, Francesco Venturoli, Giovanni Farruggia, Giovanna RSC Adv Chemistry A fluorescent derivative of trehalose with two dansyl groups (DAT) has been synthesized. It is characterised by a large Stokes shift, good permeability in human living cells and a well detectable fluorescent signal within the cells. Notably, in intestinal cells DAT is sequestered in vesicles induced by trehalose pre-treatment and colocalizes with lipid droplets. The Royal Society of Chemistry 2019-05-16 /pmc/articles/PMC9064201/ /pubmed/35514834 http://dx.doi.org/10.1039/c9ra01800j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Locatelli, Alessandra
Iommarini, Luisa
Graziadio, Alessandra
Leoni, Alberto
Porcelli, Anna Maria
Iotti, Stefano
Malucelli, Emil
Francia, Francesco
Venturoli, Giovanni
Farruggia, Giovanna
Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
title Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
title_full Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
title_fullStr Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
title_full_unstemmed Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
title_short Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
title_sort dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064201/
https://www.ncbi.nlm.nih.gov/pubmed/35514834
http://dx.doi.org/10.1039/c9ra01800j
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