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A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response

The mitochondrial unfolded protein response (UPR(mt)) has emerged as a predominant mechanism that preserves mitochondrial function. Consequently, multiple pathways likely exist to modulate UPR(mt). We discovered that the tRNA processing enzyme, homolog of ELAC2 (HOE-1), is key to UPR(mt) regulation...

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Detalles Bibliográficos
Autores principales:	Held, James P, Feng, Gaomin, Saunders, Benjamin R, Pereira, Claudia V, Burkewitz, Kristopher, Patel, Maulik R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064297/ https://www.ncbi.nlm.nih.gov/pubmed/35451962 http://dx.doi.org/10.7554/eLife.71634

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