Cargando…

The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

Genotoxic agents remain the mainstay of cancer treatment. Unfortunately, the clinical benefits are often countered by a rapid tumor adaptive response. Here, we report that the oncoprotein B cell lymphoma 6 (BCL6) is a core component that confers solid tumor adaptive resistance to genotoxic stress. M...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yanan, Feng, Juanjuan, Yuan, Kun, Wu, Zhengzhen, Hu, Longmiao, Lu, Yue, Li, Kun, Guo, Jiawei, Chen, Jing, Ma, Chengbin, Pang, Xiufeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064299/ https://www.ncbi.nlm.nih.gov/pubmed/35503721 http://dx.doi.org/10.7554/eLife.69255

Ejemplares similares

A comprehensive and perspective view of oncoprotein SET in cancer
por: Bayarkhangai, Buuvee, et al.
Publicado: (2018)

Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons
por: Liu, Yanan, et al.
Publicado: (2023)

Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer
por: Feng, Juanjuan, et al.
Publicado: (2023)

Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation
por: Fu, Kai, et al.
Publicado: (2016)

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
por: Liu, Qian, et al.
Publicado: (2019)

miR‐140‐3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2
por: Liu, Dingsheng, et al.
Publicado: (2021)

Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAF(V600E) oncoprotein kinase
por: van Veen, J Edward, et al.
Publicado: (2019)

Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O(6)-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine
por: Wei, Wei, et al.
Publicado: (2011)

Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
por: Tharp, Marla E., et al.
Publicado: (2020)

Merkel cell polyomavirus oncoproteins induce microRNAs that suppress multiple autophagy genes
por: Kumar, Satendra, et al.
Publicado: (2019)

Homoharringtonine combined with aclarubicin and cytarabine synergistically induces apoptosis in t(8;21) leukemia cells and triggers caspase‐3‐mediated cleavage of the AML1‐ETO oncoprotein
por: Cao, Jiang, et al.
Publicado: (2016)

BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer
por: Li, Kun, et al.
Publicado: (2022)

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
por: Berger, Stephanie, et al.
Publicado: (2016)

Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma
por: Dai, Wei, et al.
Publicado: (2015)

HOXA10 induces BCL2 expression, inhibits apoptosis, and promotes cell proliferation in gastric cancer
por: Song, Chenlong, et al.
Publicado: (2019)

Nonconserved miR‐608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase‐3 pathways by targeting the 3′‐UTRs of RAC2/BCL2L1 and the coding region of PAK4
por: Zhang, Xu, et al.
Publicado: (2019)

Up‐regulation of miR‐497 confers resistance to temozolomide in human glioma cells by targeting mTOR/Bcl‐2
por: Zhu, Danhua, et al.
Publicado: (2017)

MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs
por: Wood, C David, et al.
Publicado: (2016)

MiR‐335‐5p restores cisplatin sensitivity in ovarian cancer cells through targeting BCL2L2
por: Liu, Ruonan, et al.
Publicado: (2018)

225Ac‐labeled CD33‐targeting antibody reverses resistance to Bcl‐2 inhibitor venetoclax in acute myeloid leukemia models
por: Garg, Ravendra, et al.
Publicado: (2020)

Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors
por: Cittelly, Diana M., et al.
Publicado: (2010)

Topography of cancer-associated immune cells in human solid tumors
por: Kather, Jakob Nikolas, et al.
Publicado: (2018)

Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress
por: Liao, Yiji, et al.
Publicado: (2022)

The SET oncoprotein promotes estrogen-induced transcription by facilitating establishment of active chromatin
por: Guo, Changying, et al.
Publicado: (2023)

BACH1 promotes the progression of esophageal squamous cell carcinoma by inducing the epithelial–mesenchymal transition and angiogenesis
por: Zhao, Yan, et al.
Publicado: (2021)

A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes
por: Carrami, Eli M, et al.
Publicado: (2020)

Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients
por: Starrett, Gabriel J, et al.
Publicado: (2023)

The combination of a sphingosine kinase 2 inhibitor (ABC294640) and a Bcl‐2 inhibitor (ABT‐199) displays synergistic anti‐myeloma effects in myeloma cells without a t(11;14) translocation
por: Sundaramoorthy, Pasupathi, et al.
Publicado: (2018)

Fat mass and obesity‐associated protein regulates tumorigenesis of arecoline‐promoted human oral carcinoma
por: Li, Xia, et al.
Publicado: (2021)

Dermal fibroblasts induce cell cycle arrest and block epithelial–mesenchymal transition to inhibit the early stage melanoma development
por: Zhou, Linli, et al.
Publicado: (2016)

Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein
por: Janssen, Kobe, et al.
Publicado: (2023)

Nuclear overexpression of bcl-2 oncoprotein during the progression of human stomach cancer.
por: Lee, S. S., et al.
Publicado: (1998)

Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells
por: Zamora, Ruben, et al.
Publicado: (2010)

Histopathological Evaluation and Analysis of Immunohistochemical Expression of Bcl-2 Oncoprotein in Colorectal Carcinoma
por: T Patil, Shilpa, et al.
Publicado: (2019)

Long noncoding RNA NORAD is upregulated in epithelial ovarian cancer and its downregulation suppressed cancer cell functions by competing with miR‐155‐5p
por: Tong, Lingling, et al.
Publicado: (2019)

Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
por: Horrigan, Stephen K
Publicado: (2017)

Selective Vulnerability of Senescent Glioblastoma Cells to BCL-XL Inhibition
por: Rahman, Masum, et al.
Publicado: (2022)

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab
por: Kato, Daiki, et al.
Publicado: (2020)

Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder
por: Guo, Jiawei, et al.
Publicado: (2016)

Transcriptome profiling reveals novel gene expression signatures and regulating transcription factors of TGF β‐induced epithelial‐to‐mesenchymal transition
por: Du, Liutao, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t5respgb315bif9g9b3ng1jjd0