Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951

The following compounds were isolated from acetate extracts of Chaetomium globosum 7951 solid cultures: demethylchaetocochin C (1) and chaetoperazine A (3), two new epipolythiodioxopiperazine (ETP) alkaloids, a novel pyridine benzamide, 4-formyl-N-(3′-hydroxypyridin-2′-yl) benzamide (6), and three k...

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Detalles Bibliográficos
Autores principales: Wang, Fang, Zhao, Wuli, Zhang, Conghui, Chang, Shanshan, Shao, Rongguang, Xing, Jianguo, Chen, Minghua, Zhang, Yixuan, Si, Shuyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064350/
https://www.ncbi.nlm.nih.gov/pubmed/35521380
http://dx.doi.org/10.1039/c9ra02647a
Descripción
Sumario:The following compounds were isolated from acetate extracts of Chaetomium globosum 7951 solid cultures: demethylchaetocochin C (1) and chaetoperazine A (3), two new epipolythiodioxopiperazine (ETP) alkaloids, a novel pyridine benzamide, 4-formyl-N-(3′-hydroxypyridin-2′-yl) benzamide (6), and three known ETP derivatives (2, 4, and 5). The structures of these compounds were determined using extensive spectroscopic data analysis. Compounds 1–3, and 6, inhibited the growth of MCF-7, MDA-MB-231, H460 and HCT-8 cells with an IC(50) of 4.5 to 65.0 μM.

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