Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951

The following compounds were isolated from acetate extracts of Chaetomium globosum 7951 solid cultures: demethylchaetocochin C (1) and chaetoperazine A (3), two new epipolythiodioxopiperazine (ETP) alkaloids, a novel pyridine benzamide, 4-formyl-N-(3′-hydroxypyridin-2′-yl) benzamide (6), and three k...

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Autores principales: Wang, Fang, Zhao, Wuli, Zhang, Conghui, Chang, Shanshan, Shao, Rongguang, Xing, Jianguo, Chen, Minghua, Zhang, Yixuan, Si, Shuyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064350/
https://www.ncbi.nlm.nih.gov/pubmed/35521380
http://dx.doi.org/10.1039/c9ra02647a
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author Wang, Fang
Zhao, Wuli
Zhang, Conghui
Chang, Shanshan
Shao, Rongguang
Xing, Jianguo
Chen, Minghua
Zhang, Yixuan
Si, Shuyi
author_facet Wang, Fang
Zhao, Wuli
Zhang, Conghui
Chang, Shanshan
Shao, Rongguang
Xing, Jianguo
Chen, Minghua
Zhang, Yixuan
Si, Shuyi
author_sort Wang, Fang
collection PubMed
description The following compounds were isolated from acetate extracts of Chaetomium globosum 7951 solid cultures: demethylchaetocochin C (1) and chaetoperazine A (3), two new epipolythiodioxopiperazine (ETP) alkaloids, a novel pyridine benzamide, 4-formyl-N-(3′-hydroxypyridin-2′-yl) benzamide (6), and three known ETP derivatives (2, 4, and 5). The structures of these compounds were determined using extensive spectroscopic data analysis. Compounds 1–3, and 6, inhibited the growth of MCF-7, MDA-MB-231, H460 and HCT-8 cells with an IC(50) of 4.5 to 65.0 μM.
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spelling pubmed-90643502022-05-04 Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951 Wang, Fang Zhao, Wuli Zhang, Conghui Chang, Shanshan Shao, Rongguang Xing, Jianguo Chen, Minghua Zhang, Yixuan Si, Shuyi RSC Adv Chemistry The following compounds were isolated from acetate extracts of Chaetomium globosum 7951 solid cultures: demethylchaetocochin C (1) and chaetoperazine A (3), two new epipolythiodioxopiperazine (ETP) alkaloids, a novel pyridine benzamide, 4-formyl-N-(3′-hydroxypyridin-2′-yl) benzamide (6), and three known ETP derivatives (2, 4, and 5). The structures of these compounds were determined using extensive spectroscopic data analysis. Compounds 1–3, and 6, inhibited the growth of MCF-7, MDA-MB-231, H460 and HCT-8 cells with an IC(50) of 4.5 to 65.0 μM. The Royal Society of Chemistry 2019-05-21 /pmc/articles/PMC9064350/ /pubmed/35521380 http://dx.doi.org/10.1039/c9ra02647a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wang, Fang
Zhao, Wuli
Zhang, Conghui
Chang, Shanshan
Shao, Rongguang
Xing, Jianguo
Chen, Minghua
Zhang, Yixuan
Si, Shuyi
Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951
title Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951
title_full Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951
title_fullStr Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951
title_full_unstemmed Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951
title_short Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951
title_sort cytotoxic metabolites from the endophytic fungus chaetomium globosum 7951
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064350/
https://www.ncbi.nlm.nih.gov/pubmed/35521380
http://dx.doi.org/10.1039/c9ra02647a
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