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In situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals

The present study aimed to develop and validate an advanced image stitching algorithm integrated with chemical imaging at the nanometre scale. This was applied to track the swelling, erosion, drug release and changes in surface texture of a swelling-controlled release system. The technique involves...

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Detalles Bibliográficos
Autores principales: Nirwan, Jorabar Singh, Conway, Barbara R., Ghori, Muhammad Usman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064367/
https://www.ncbi.nlm.nih.gov/pubmed/35521370
http://dx.doi.org/10.1039/c9ra01434a
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author Nirwan, Jorabar Singh
Conway, Barbara R.
Ghori, Muhammad Usman
author_facet Nirwan, Jorabar Singh
Conway, Barbara R.
Ghori, Muhammad Usman
author_sort Nirwan, Jorabar Singh
collection PubMed
description The present study aimed to develop and validate an advanced image stitching algorithm integrated with chemical imaging at the nanometre scale. This was applied to track the swelling, erosion, drug release and changes in surface texture of a swelling-controlled release system. The technique involves the delivery and withdrawal of a liquid droplet from the surface of the tablet alongside capturing multiple images of tablet surface using white light profilometry. The recovered liquid was then subject to chemical analysis for the quantification of drug and HPMC. The multiple images acquired during drug release were stitched together using an algorithm developed to generate a full tablet surface. New methods for swelling analysis (regional point, area and multiple regional analysis techniques) were also successfully developed. The results exhibited the exceptional capability of this technique for providing quantitative information regarding swelling, erosion, drug release and surface topography, hence negating the need for separate investigations. Moreover, it can also be anticipated that this technique may have potential use in other fields where surface dissolution, erosion and swelling have significant impact.
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spelling pubmed-90643672022-05-04 In situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals Nirwan, Jorabar Singh Conway, Barbara R. Ghori, Muhammad Usman RSC Adv Chemistry The present study aimed to develop and validate an advanced image stitching algorithm integrated with chemical imaging at the nanometre scale. This was applied to track the swelling, erosion, drug release and changes in surface texture of a swelling-controlled release system. The technique involves the delivery and withdrawal of a liquid droplet from the surface of the tablet alongside capturing multiple images of tablet surface using white light profilometry. The recovered liquid was then subject to chemical analysis for the quantification of drug and HPMC. The multiple images acquired during drug release were stitched together using an algorithm developed to generate a full tablet surface. New methods for swelling analysis (regional point, area and multiple regional analysis techniques) were also successfully developed. The results exhibited the exceptional capability of this technique for providing quantitative information regarding swelling, erosion, drug release and surface topography, hence negating the need for separate investigations. Moreover, it can also be anticipated that this technique may have potential use in other fields where surface dissolution, erosion and swelling have significant impact. The Royal Society of Chemistry 2019-05-30 /pmc/articles/PMC9064367/ /pubmed/35521370 http://dx.doi.org/10.1039/c9ra01434a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Nirwan, Jorabar Singh
Conway, Barbara R.
Ghori, Muhammad Usman
In situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals
title In situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals
title_full In situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals
title_fullStr In situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals
title_full_unstemmed In situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals
title_short In situ 3D nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals
title_sort in situ 3d nanoscale advanced imaging algorithms with integrated chemical imaging for the characterisation of pharmaceuticals
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064367/
https://www.ncbi.nlm.nih.gov/pubmed/35521370
http://dx.doi.org/10.1039/c9ra01434a
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