Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia

Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging. We prepared GNRs with hypoxia-targeting nitroimidazole units (G-NI) on their surface. Biological experiments revealed that G-NI produced a strong photoacoustic signa...

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Detalles Bibliográficos
Autores principales: Umehara, Yui, Kageyama, Toki, Son, Aoi, Kimura, Yu, Kondo, Teruyuki, Tanabe, Kazuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064429/
https://www.ncbi.nlm.nih.gov/pubmed/35516361
http://dx.doi.org/10.1039/c9ra00951e
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author Umehara, Yui
Kageyama, Toki
Son, Aoi
Kimura, Yu
Kondo, Teruyuki
Tanabe, Kazuhito
author_facet Umehara, Yui
Kageyama, Toki
Son, Aoi
Kimura, Yu
Kondo, Teruyuki
Tanabe, Kazuhito
author_sort Umehara, Yui
collection PubMed
description Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging. We prepared GNRs with hypoxia-targeting nitroimidazole units (G-NI) on their surface. Biological experiments revealed that G-NI produced a strong photoacoustic signal in hypoxic tumor cells and tissues.
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spelling pubmed-90644292022-05-04 Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia Umehara, Yui Kageyama, Toki Son, Aoi Kimura, Yu Kondo, Teruyuki Tanabe, Kazuhito RSC Adv Chemistry Tumor-selective accumulation of gold nanorods (GNR) has been demonstrated for visualization of tumor hypoxia by photoacoustic imaging. We prepared GNRs with hypoxia-targeting nitroimidazole units (G-NI) on their surface. Biological experiments revealed that G-NI produced a strong photoacoustic signal in hypoxic tumor cells and tissues. The Royal Society of Chemistry 2019-05-29 /pmc/articles/PMC9064429/ /pubmed/35516361 http://dx.doi.org/10.1039/c9ra00951e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Umehara, Yui
Kageyama, Toki
Son, Aoi
Kimura, Yu
Kondo, Teruyuki
Tanabe, Kazuhito
Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia
title Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia
title_full Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia
title_fullStr Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia
title_full_unstemmed Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia
title_short Biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia
title_sort biological reduction of nitroimidazole-functionalized gold nanorods for photoacoustic imaging of tumor hypoxia
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064429/
https://www.ncbi.nlm.nih.gov/pubmed/35516361
http://dx.doi.org/10.1039/c9ra00951e
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