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Ethnopharmacological Study of the Medicinal Plants Used in the Treatment of Sickle Cell Anemia in the West Region of Cameroon

BACKGROUND: Sickle cell anemia (SCA) or sickle cell disease (SCD) is a genetic disease associated with increased morbidity and mortality in Africa and other developing nations. Therefore, modern and traditional remedies are being introduced for use in the treatment and management of this disease. Th...

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Autores principales: Yembeau, Natacha Lena, Biapa Nya, Prosper Cabral, Pieme, Constant Anatole, Tchouane, Kevin Dedjam, Kengne Fotsing, Christian Bernard, Nya Nkwikeu, Prudence Josela, Feudjio, Alfloditte Flore, Telefo, Phelix Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064533/
https://www.ncbi.nlm.nih.gov/pubmed/35518347
http://dx.doi.org/10.1155/2022/5098428
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author Yembeau, Natacha Lena
Biapa Nya, Prosper Cabral
Pieme, Constant Anatole
Tchouane, Kevin Dedjam
Kengne Fotsing, Christian Bernard
Nya Nkwikeu, Prudence Josela
Feudjio, Alfloditte Flore
Telefo, Phelix Bruno
author_facet Yembeau, Natacha Lena
Biapa Nya, Prosper Cabral
Pieme, Constant Anatole
Tchouane, Kevin Dedjam
Kengne Fotsing, Christian Bernard
Nya Nkwikeu, Prudence Josela
Feudjio, Alfloditte Flore
Telefo, Phelix Bruno
author_sort Yembeau, Natacha Lena
collection PubMed
description BACKGROUND: Sickle cell anemia (SCA) or sickle cell disease (SCD) is a genetic disease associated with increased morbidity and mortality in Africa and other developing nations. Therefore, modern and traditional remedies are being introduced for use in the treatment and management of this disease. This is because safe, effective, and inexpensive therapeutic agents are urgently needed for the treatment of this disease in Africa and other developing nations. OBJECTIVE: The purpose of this study is to identify medicinal plant species commonly used by traditional healers in the treatment of sickle cell patients across some localities in the west region of Cameroon. Material and Methods. The ethnopharmacological survey was carried out in several districts within some localities of the western region of Cameroon. The survey was based on a semistructured questionnaire that was administered to 17 traditional healers and 62 sickle cell patients. It took place between November 2018 and March 2019. Personal information of participants and plant therapy data were gathered. Plants were identified at the National Herbarium of Cameroon. Literature review determined pharmacological effects and phytochemical compounds of the identified plants. Data were generally analysed using Epi Info 7 software for Windows. RESULTS: Twelve medicinal plant species belonging to 10 families are being used in the treatment of sickle cell anemia across the study sites. Euphorbiaceae is the dominant family with three plant species. Bark (39.3%) and seeds (35.7%) are the most used plant parts, which get administered through maceration, decoction, and chewing in water. According to the literature review, the identified plants have pharmacological effects and phytochemical compounds (especially polyphenols and alkaloids) that signify the presence of antioxidant compounds, which may possess an antisickling activity. There is therefore a need to conduct another study to scientifically validate (in vitro) antisickling properties of these plants. CONCLUSION: This study has revealed promising medicinal plants that are currently applied in the traditional treatment of sickle cell anemia. Although still inconclusive, the association of pharmacological effects and phytochemical compounds with these medicinal plants justifies their use in traditional pharmacopoeia.
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spelling pubmed-90645332022-05-04 Ethnopharmacological Study of the Medicinal Plants Used in the Treatment of Sickle Cell Anemia in the West Region of Cameroon Yembeau, Natacha Lena Biapa Nya, Prosper Cabral Pieme, Constant Anatole Tchouane, Kevin Dedjam Kengne Fotsing, Christian Bernard Nya Nkwikeu, Prudence Josela Feudjio, Alfloditte Flore Telefo, Phelix Bruno Evid Based Complement Alternat Med Research Article BACKGROUND: Sickle cell anemia (SCA) or sickle cell disease (SCD) is a genetic disease associated with increased morbidity and mortality in Africa and other developing nations. Therefore, modern and traditional remedies are being introduced for use in the treatment and management of this disease. This is because safe, effective, and inexpensive therapeutic agents are urgently needed for the treatment of this disease in Africa and other developing nations. OBJECTIVE: The purpose of this study is to identify medicinal plant species commonly used by traditional healers in the treatment of sickle cell patients across some localities in the west region of Cameroon. Material and Methods. The ethnopharmacological survey was carried out in several districts within some localities of the western region of Cameroon. The survey was based on a semistructured questionnaire that was administered to 17 traditional healers and 62 sickle cell patients. It took place between November 2018 and March 2019. Personal information of participants and plant therapy data were gathered. Plants were identified at the National Herbarium of Cameroon. Literature review determined pharmacological effects and phytochemical compounds of the identified plants. Data were generally analysed using Epi Info 7 software for Windows. RESULTS: Twelve medicinal plant species belonging to 10 families are being used in the treatment of sickle cell anemia across the study sites. Euphorbiaceae is the dominant family with three plant species. Bark (39.3%) and seeds (35.7%) are the most used plant parts, which get administered through maceration, decoction, and chewing in water. According to the literature review, the identified plants have pharmacological effects and phytochemical compounds (especially polyphenols and alkaloids) that signify the presence of antioxidant compounds, which may possess an antisickling activity. There is therefore a need to conduct another study to scientifically validate (in vitro) antisickling properties of these plants. CONCLUSION: This study has revealed promising medicinal plants that are currently applied in the traditional treatment of sickle cell anemia. Although still inconclusive, the association of pharmacological effects and phytochemical compounds with these medicinal plants justifies their use in traditional pharmacopoeia. Hindawi 2022-04-26 /pmc/articles/PMC9064533/ /pubmed/35518347 http://dx.doi.org/10.1155/2022/5098428 Text en Copyright © 2022 Natacha Lena Yembeau et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yembeau, Natacha Lena
Biapa Nya, Prosper Cabral
Pieme, Constant Anatole
Tchouane, Kevin Dedjam
Kengne Fotsing, Christian Bernard
Nya Nkwikeu, Prudence Josela
Feudjio, Alfloditte Flore
Telefo, Phelix Bruno
Ethnopharmacological Study of the Medicinal Plants Used in the Treatment of Sickle Cell Anemia in the West Region of Cameroon
title Ethnopharmacological Study of the Medicinal Plants Used in the Treatment of Sickle Cell Anemia in the West Region of Cameroon
title_full Ethnopharmacological Study of the Medicinal Plants Used in the Treatment of Sickle Cell Anemia in the West Region of Cameroon
title_fullStr Ethnopharmacological Study of the Medicinal Plants Used in the Treatment of Sickle Cell Anemia in the West Region of Cameroon
title_full_unstemmed Ethnopharmacological Study of the Medicinal Plants Used in the Treatment of Sickle Cell Anemia in the West Region of Cameroon
title_short Ethnopharmacological Study of the Medicinal Plants Used in the Treatment of Sickle Cell Anemia in the West Region of Cameroon
title_sort ethnopharmacological study of the medicinal plants used in the treatment of sickle cell anemia in the west region of cameroon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064533/
https://www.ncbi.nlm.nih.gov/pubmed/35518347
http://dx.doi.org/10.1155/2022/5098428
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