Cargando…
UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis
Eleven novel uncommon single ether linkage dimeric 2-(2-phenylethyl)chromones (aquilasinenones A–K) were isolated by a UPLC-MS guided method from artificial hole-induced agarwood originating from Aquilaria sinensis. Their structures were unambiguously deduced using HRESIMS data, detailed 1D and 2D N...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064565/ https://www.ncbi.nlm.nih.gov/pubmed/35519867 http://dx.doi.org/10.1039/c9ra02597a |
| _version_ | 1784699407307898880 |
|---|---|
| author | Kuang, Tongdong Chen, Hui-Qin Wang, Hao Kong, Fan-Dong Cai, Cai-Hong Dong, Wen-Hua Yuan, Jing-Zhe Mei, Wen-Li Dai, Hao-Fu |
| author_facet | Kuang, Tongdong Chen, Hui-Qin Wang, Hao Kong, Fan-Dong Cai, Cai-Hong Dong, Wen-Hua Yuan, Jing-Zhe Mei, Wen-Li Dai, Hao-Fu |
| author_sort | Kuang, Tongdong |
| collection | PubMed |
| description | Eleven novel uncommon single ether linkage dimeric 2-(2-phenylethyl)chromones (aquilasinenones A–K) were isolated by a UPLC-MS guided method from artificial hole-induced agarwood originating from Aquilaria sinensis. Their structures were unambiguously deduced using HRESIMS data, detailed 1D and 2D NMR spectroscopic analysis, and experimental ECD spectra. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity by Ellman's colorimetric method, and compounds 9–11 displayed weak AChE inhibitory activity with the inhibition ranging from 15.6% to 16.8% at a concentration of 50 μg mL(−1). |
| format | Online Article Text |
| id | pubmed-9064565 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90645652022-05-04 UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis Kuang, Tongdong Chen, Hui-Qin Wang, Hao Kong, Fan-Dong Cai, Cai-Hong Dong, Wen-Hua Yuan, Jing-Zhe Mei, Wen-Li Dai, Hao-Fu RSC Adv Chemistry Eleven novel uncommon single ether linkage dimeric 2-(2-phenylethyl)chromones (aquilasinenones A–K) were isolated by a UPLC-MS guided method from artificial hole-induced agarwood originating from Aquilaria sinensis. Their structures were unambiguously deduced using HRESIMS data, detailed 1D and 2D NMR spectroscopic analysis, and experimental ECD spectra. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity by Ellman's colorimetric method, and compounds 9–11 displayed weak AChE inhibitory activity with the inhibition ranging from 15.6% to 16.8% at a concentration of 50 μg mL(−1). The Royal Society of Chemistry 2019-05-31 /pmc/articles/PMC9064565/ /pubmed/35519867 http://dx.doi.org/10.1039/c9ra02597a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Kuang, Tongdong Chen, Hui-Qin Wang, Hao Kong, Fan-Dong Cai, Cai-Hong Dong, Wen-Hua Yuan, Jing-Zhe Mei, Wen-Li Dai, Hao-Fu UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis |
| title | UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis |
| title_full | UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis |
| title_fullStr | UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis |
| title_full_unstemmed | UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis |
| title_short | UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis |
| title_sort | uplc-ms-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from aquilaria sinensis |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064565/ https://www.ncbi.nlm.nih.gov/pubmed/35519867 http://dx.doi.org/10.1039/c9ra02597a |
| work_keys_str_mv | AT kuangtongdong uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis AT chenhuiqin uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis AT wanghao uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis AT kongfandong uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis AT caicaihong uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis AT dongwenhua uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis AT yuanjingzhe uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis AT meiwenli uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis AT daihaofu uplcmsguidedisolationofsingleetherlinkagedimeric22phenylethylchromonesfromaquilariasinensis |