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Pre-Steady-State Reactivity of Peptidylglycine Monooxygenase Implicates Ascorbate in Substrate Triggering of the Active Conformer

[Image: see text] Peptidylglycine monooxygenase (PHM) is essential for the posttranslational amidation of neuroendocrine peptides. An important aspect of the PHM mechanism is the complete coupling of oxygen reduction to substrate hydroxylation, which implies no oxygen reactivity of the fully reduced...

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Detalles Bibliográficos
Autores principales:	Welch, Evan F., Rush, Katherine W., Arias, Renee J., Blackburn, Ninian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064607/ https://www.ncbi.nlm.nih.gov/pubmed/35380039 http://dx.doi.org/10.1021/acs.biochem.2c00080

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