Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines

A catalytic amount of CuCl and Cs(2)CO(3) was employed to synthesize a variety of 2-substituted benzo[b]furans and indoles by an intramolecular cyclization of 2-alkynyl phenols and tosylanilines. This protocol features mild conditions, high yields and broad substrate scope, which makes it a practica...

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Detalles Bibliográficos
Autores principales: Rong, Zhouting, Gao, Kexin, Zhou, Lei, Lin, Jianyuan, Qian, Guoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064688/
https://www.ncbi.nlm.nih.gov/pubmed/35520559
http://dx.doi.org/10.1039/c9ra01260e
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author Rong, Zhouting
Gao, Kexin
Zhou, Lei
Lin, Jianyuan
Qian, Guoying
author_facet Rong, Zhouting
Gao, Kexin
Zhou, Lei
Lin, Jianyuan
Qian, Guoying
author_sort Rong, Zhouting
collection PubMed
description A catalytic amount of CuCl and Cs(2)CO(3) was employed to synthesize a variety of 2-substituted benzo[b]furans and indoles by an intramolecular cyclization of 2-alkynyl phenols and tosylanilines. This protocol features mild conditions, high yields and broad substrate scope, which makes it a practical method for the synthesis of 2-substituted benzo[b]furans and indoles.
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spelling pubmed-90646882022-05-04 Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines Rong, Zhouting Gao, Kexin Zhou, Lei Lin, Jianyuan Qian, Guoying RSC Adv Chemistry A catalytic amount of CuCl and Cs(2)CO(3) was employed to synthesize a variety of 2-substituted benzo[b]furans and indoles by an intramolecular cyclization of 2-alkynyl phenols and tosylanilines. This protocol features mild conditions, high yields and broad substrate scope, which makes it a practical method for the synthesis of 2-substituted benzo[b]furans and indoles. The Royal Society of Chemistry 2019-06-07 /pmc/articles/PMC9064688/ /pubmed/35520559 http://dx.doi.org/10.1039/c9ra01260e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Rong, Zhouting
Gao, Kexin
Zhou, Lei
Lin, Jianyuan
Qian, Guoying
Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines
title Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines
title_full Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines
title_fullStr Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines
title_full_unstemmed Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines
title_short Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines
title_sort facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064688/
https://www.ncbi.nlm.nih.gov/pubmed/35520559
http://dx.doi.org/10.1039/c9ra01260e
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