COVID-19-Associated Pulmonary Aspergillosis in a Patient Treated With Remdesivir, Dexamethasone, and Baricitinib: A Case Report

Remdesivir, dexamethasone, and baricitinib have recently been used to treat patients with coronavirus disease 2019 (COVID-19) and respiratory failure. However, the adverse effects of combination therapy have not been fully explored. A 64-year-old man was diagnosed with COVID-19 and was treated with...

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Autores principales: Shimada, Ayako, Ohnaka, Shinnosuke, Kubo, Kosumi, Nakashima, Masanao, Nagai, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Radiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064704/
https://www.ncbi.nlm.nih.gov/pubmed/35518522
http://dx.doi.org/10.7759/cureus.23755
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author Shimada, Ayako
Ohnaka, Shinnosuke
Kubo, Kosumi
Nakashima, Masanao
Nagai, Atsushi
author_facet Shimada, Ayako
Ohnaka, Shinnosuke
Kubo, Kosumi
Nakashima, Masanao
Nagai, Atsushi
author_sort Shimada, Ayako
collection PubMed
description Remdesivir, dexamethasone, and baricitinib have recently been used to treat patients with coronavirus disease 2019 (COVID-19) and respiratory failure. However, the adverse effects of combination therapy have not been fully explored. A 64-year-old man was diagnosed with COVID-19 and was treated with remdesivir, dexamethasone, and baricitinib. His respiratory condition worsened on day 17, and in the following days, he was diagnosed with pneumomediastinum and COVID-19-associated pulmonary aspergillosis (CAPA). His condition improved with a reduction in the corticosteroid regime and antifungal treatment. This is the first case of pulmonary aspergillosis in a patient with COVID-19 that was treated with remdesivir, dexamethasone, and baricitinib.
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spelling pubmed-90647042022-05-04 COVID-19-Associated Pulmonary Aspergillosis in a Patient Treated With Remdesivir, Dexamethasone, and Baricitinib: A Case Report Shimada, Ayako Ohnaka, Shinnosuke Kubo, Kosumi Nakashima, Masanao Nagai, Atsushi Cureus Radiology Remdesivir, dexamethasone, and baricitinib have recently been used to treat patients with coronavirus disease 2019 (COVID-19) and respiratory failure. However, the adverse effects of combination therapy have not been fully explored. A 64-year-old man was diagnosed with COVID-19 and was treated with remdesivir, dexamethasone, and baricitinib. His respiratory condition worsened on day 17, and in the following days, he was diagnosed with pneumomediastinum and COVID-19-associated pulmonary aspergillosis (CAPA). His condition improved with a reduction in the corticosteroid regime and antifungal treatment. This is the first case of pulmonary aspergillosis in a patient with COVID-19 that was treated with remdesivir, dexamethasone, and baricitinib. Cureus 2022-04-02 /pmc/articles/PMC9064704/ /pubmed/35518522 http://dx.doi.org/10.7759/cureus.23755 Text en Copyright © 2022, Shimada et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiology
Shimada, Ayako
Ohnaka, Shinnosuke
Kubo, Kosumi
Nakashima, Masanao
Nagai, Atsushi
COVID-19-Associated Pulmonary Aspergillosis in a Patient Treated With Remdesivir, Dexamethasone, and Baricitinib: A Case Report
title COVID-19-Associated Pulmonary Aspergillosis in a Patient Treated With Remdesivir, Dexamethasone, and Baricitinib: A Case Report
title_full COVID-19-Associated Pulmonary Aspergillosis in a Patient Treated With Remdesivir, Dexamethasone, and Baricitinib: A Case Report
title_fullStr COVID-19-Associated Pulmonary Aspergillosis in a Patient Treated With Remdesivir, Dexamethasone, and Baricitinib: A Case Report
title_full_unstemmed COVID-19-Associated Pulmonary Aspergillosis in a Patient Treated With Remdesivir, Dexamethasone, and Baricitinib: A Case Report
title_short COVID-19-Associated Pulmonary Aspergillosis in a Patient Treated With Remdesivir, Dexamethasone, and Baricitinib: A Case Report
title_sort covid-19-associated pulmonary aspergillosis in a patient treated with remdesivir, dexamethasone, and baricitinib: a case report
topic Radiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064704/
https://www.ncbi.nlm.nih.gov/pubmed/35518522
http://dx.doi.org/10.7759/cureus.23755
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