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Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study
BACKGROUND: There are limited numbers of studies focusing on renal effects of coronavirus disease 2019 (COVID-19) infection and proximal tubular dysfunction in children with COVID-19 infections. The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children w...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064720/ https://www.ncbi.nlm.nih.gov/pubmed/35505147 http://dx.doi.org/10.1007/s12519-022-00552-2 |
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author | Devrim, Fatma Böncüoğlu, Elif Kıymet, Elif Şahinkaya, Şahika Cem, Ela Düzgöl, Mine Kara, Aybüke Akaslan Arıkan, Kamile Ötiken Kantar, Aslı Yılmaz, Ebru Dinçel, Nida Bayram, Nuri Devrim, İlker |
author_facet | Devrim, Fatma Böncüoğlu, Elif Kıymet, Elif Şahinkaya, Şahika Cem, Ela Düzgöl, Mine Kara, Aybüke Akaslan Arıkan, Kamile Ötiken Kantar, Aslı Yılmaz, Ebru Dinçel, Nida Bayram, Nuri Devrim, İlker |
author_sort | Devrim, Fatma |
collection | PubMed |
description | BACKGROUND: There are limited numbers of studies focusing on renal effects of coronavirus disease 2019 (COVID-19) infection and proximal tubular dysfunction in children with COVID-19 infections. The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confirmed acute COVID-19. METHODS: The children who were hospitalized for confirmed COVID-19 were included in this prospective descriptive analysis. The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury: abnormal tubular reabsorption of phosphate, normoglycemic glycosuria, hyperuricosuria, and proteinuria. RESULTS: A total of 115 patients were included in the study. About a third of the individuals had elevated blood creatinine levels or proteinuria. In addition, abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10 (8.7%) patients, as was hyperuricosuria in 28.6%. As a result, total proximal tubular dysfunction was found in 24 (20.9%) patients. CONCLUSIONS: One in every five children with acute COVID-19 infections had proximal tubular dysfunction, according to our data. Although, the rate of proximal tubular dysfunction was lower than in adults, it should be noted. The recovery of proximal tubular function in children with COVID-19 should be followed. |
format | Online Article Text |
id | pubmed-9064720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-90647202022-05-04 Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study Devrim, Fatma Böncüoğlu, Elif Kıymet, Elif Şahinkaya, Şahika Cem, Ela Düzgöl, Mine Kara, Aybüke Akaslan Arıkan, Kamile Ötiken Kantar, Aslı Yılmaz, Ebru Dinçel, Nida Bayram, Nuri Devrim, İlker World J Pediatr Original Article BACKGROUND: There are limited numbers of studies focusing on renal effects of coronavirus disease 2019 (COVID-19) infection and proximal tubular dysfunction in children with COVID-19 infections. The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confirmed acute COVID-19. METHODS: The children who were hospitalized for confirmed COVID-19 were included in this prospective descriptive analysis. The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury: abnormal tubular reabsorption of phosphate, normoglycemic glycosuria, hyperuricosuria, and proteinuria. RESULTS: A total of 115 patients were included in the study. About a third of the individuals had elevated blood creatinine levels or proteinuria. In addition, abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10 (8.7%) patients, as was hyperuricosuria in 28.6%. As a result, total proximal tubular dysfunction was found in 24 (20.9%) patients. CONCLUSIONS: One in every five children with acute COVID-19 infections had proximal tubular dysfunction, according to our data. Although, the rate of proximal tubular dysfunction was lower than in adults, it should be noted. The recovery of proximal tubular function in children with COVID-19 should be followed. Springer Nature Singapore 2022-05-04 2022 /pmc/articles/PMC9064720/ /pubmed/35505147 http://dx.doi.org/10.1007/s12519-022-00552-2 Text en © Children's Hospital, Zhejiang University School of Medicine 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Devrim, Fatma Böncüoğlu, Elif Kıymet, Elif Şahinkaya, Şahika Cem, Ela Düzgöl, Mine Kara, Aybüke Akaslan Arıkan, Kamile Ötiken Kantar, Aslı Yılmaz, Ebru Dinçel, Nida Bayram, Nuri Devrim, İlker Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study |
title | Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study |
title_full | Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study |
title_fullStr | Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study |
title_full_unstemmed | Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study |
title_short | Evaluation of proximal tubule functions in children with COVID-19: a prospective analytical study |
title_sort | evaluation of proximal tubule functions in children with covid-19: a prospective analytical study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064720/ https://www.ncbi.nlm.nih.gov/pubmed/35505147 http://dx.doi.org/10.1007/s12519-022-00552-2 |
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