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Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity
In the present study, novel dermacozine-1-carboxamides (8a–8n) were synthesized and screened for their in vitro cytotoxic activity against three different cancer cell lines: MCF-7 (breast cancer), A-549 (lung cancer) and DU145 (prostate cancer). All the compounds showed more efficiency against the D...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064817/ https://www.ncbi.nlm.nih.gov/pubmed/35515253 http://dx.doi.org/10.1039/c9ra02416f |
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author | Ghanta, Venkata Rao Madala, Nagaraju Pasula, Aparna Pindiprolu, Sai Kiran S. S. Battula, Kumara Swamy Krishnamurthy, Praveen T. Raman, Balamurali |
author_facet | Ghanta, Venkata Rao Madala, Nagaraju Pasula, Aparna Pindiprolu, Sai Kiran S. S. Battula, Kumara Swamy Krishnamurthy, Praveen T. Raman, Balamurali |
author_sort | Ghanta, Venkata Rao |
collection | PubMed |
description | In the present study, novel dermacozine-1-carboxamides (8a–8n) were synthesized and screened for their in vitro cytotoxic activity against three different cancer cell lines: MCF-7 (breast cancer), A-549 (lung cancer) and DU145 (prostate cancer). All the compounds showed more efficiency against the DU145 cell line than against the MCF-7 and A-549 cell lines. Furthermore, 8a (CTC(50): 7.02 μM) and 8l (CTC(50): 6.32 μM) have been found to be more effective against the DU145 cells as they arrest the cell cycle at the G2/M phase by interfering with tubulin polymerization; these results indicate that these compounds act as potential anti-cancer agents by inhibiting tubulin polymerization. |
format | Online Article Text |
id | pubmed-9064817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90648172022-05-04 Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity Ghanta, Venkata Rao Madala, Nagaraju Pasula, Aparna Pindiprolu, Sai Kiran S. S. Battula, Kumara Swamy Krishnamurthy, Praveen T. Raman, Balamurali RSC Adv Chemistry In the present study, novel dermacozine-1-carboxamides (8a–8n) were synthesized and screened for their in vitro cytotoxic activity against three different cancer cell lines: MCF-7 (breast cancer), A-549 (lung cancer) and DU145 (prostate cancer). All the compounds showed more efficiency against the DU145 cell line than against the MCF-7 and A-549 cell lines. Furthermore, 8a (CTC(50): 7.02 μM) and 8l (CTC(50): 6.32 μM) have been found to be more effective against the DU145 cells as they arrest the cell cycle at the G2/M phase by interfering with tubulin polymerization; these results indicate that these compounds act as potential anti-cancer agents by inhibiting tubulin polymerization. The Royal Society of Chemistry 2019-06-13 /pmc/articles/PMC9064817/ /pubmed/35515253 http://dx.doi.org/10.1039/c9ra02416f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Ghanta, Venkata Rao Madala, Nagaraju Pasula, Aparna Pindiprolu, Sai Kiran S. S. Battula, Kumara Swamy Krishnamurthy, Praveen T. Raman, Balamurali Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity |
title | Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity |
title_full | Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity |
title_fullStr | Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity |
title_full_unstemmed | Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity |
title_short | Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity |
title_sort | novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064817/ https://www.ncbi.nlm.nih.gov/pubmed/35515253 http://dx.doi.org/10.1039/c9ra02416f |
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