Synthesis and anticancer activity novel dimeric azatriperoxides

An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction of 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-,...

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Detalles Bibliográficos
Autores principales: Makhmudiyarova, Nataliya N., Ishmukhametova, Irina R., Dzhemileva, Lilya U., Tyumkina, Tatyana V., D'yakonov, Vladimir A., Ibragimov, Askhat G., Dzhemilev, Usein M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064891/
https://www.ncbi.nlm.nih.gov/pubmed/35516904
http://dx.doi.org/10.1039/c9ra02950h
Descripción
Sumario:An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction of 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-, 1,5-pentane-, 1,7-heptane-, 1,8-octane- and 1,10-decanediamines) catalyzed by Sm(NO(3))(3)/γ-Al(2)O(3). Using flow cytometry, it was shown for the first time that synthesized dimeric azatriperoxides are efficient apoptosis inducers with Jurkat, K562, U937, and Hek296.

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