Synthesis and anticancer activity novel dimeric azatriperoxides

An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction of 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-,...

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Autores principales: Makhmudiyarova, Nataliya N., Ishmukhametova, Irina R., Dzhemileva, Lilya U., Tyumkina, Tatyana V., D'yakonov, Vladimir A., Ibragimov, Askhat G., Dzhemilev, Usein M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064891/
https://www.ncbi.nlm.nih.gov/pubmed/35516904
http://dx.doi.org/10.1039/c9ra02950h
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author Makhmudiyarova, Nataliya N.
Ishmukhametova, Irina R.
Dzhemileva, Lilya U.
Tyumkina, Tatyana V.
D'yakonov, Vladimir A.
Ibragimov, Askhat G.
Dzhemilev, Usein M.
author_facet Makhmudiyarova, Nataliya N.
Ishmukhametova, Irina R.
Dzhemileva, Lilya U.
Tyumkina, Tatyana V.
D'yakonov, Vladimir A.
Ibragimov, Askhat G.
Dzhemilev, Usein M.
author_sort Makhmudiyarova, Nataliya N.
collection PubMed
description An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction of 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-, 1,5-pentane-, 1,7-heptane-, 1,8-octane- and 1,10-decanediamines) catalyzed by Sm(NO(3))(3)/γ-Al(2)O(3). Using flow cytometry, it was shown for the first time that synthesized dimeric azatriperoxides are efficient apoptosis inducers with Jurkat, K562, U937, and Hek296.
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spelling pubmed-90648912022-05-04 Synthesis and anticancer activity novel dimeric azatriperoxides Makhmudiyarova, Nataliya N. Ishmukhametova, Irina R. Dzhemileva, Lilya U. Tyumkina, Tatyana V. D'yakonov, Vladimir A. Ibragimov, Askhat G. Dzhemilev, Usein M. RSC Adv Chemistry An efficient method was developed for the synthesis of tetra(spirocycloalkane)-substituted α,ω-di(1,2,4,5,7,8-hexaoxa-10-azacycloundecan-10-yl)alkanes by a ring transformation reaction of 3,6-di(spirocycloalkane)-substituted 1,2,4,5,7,8,10-heptaoxacycloundecanes with α,ω-alkanediamines (1,4-butane-, 1,5-pentane-, 1,7-heptane-, 1,8-octane- and 1,10-decanediamines) catalyzed by Sm(NO(3))(3)/γ-Al(2)O(3). Using flow cytometry, it was shown for the first time that synthesized dimeric azatriperoxides are efficient apoptosis inducers with Jurkat, K562, U937, and Hek296. The Royal Society of Chemistry 2019-06-17 /pmc/articles/PMC9064891/ /pubmed/35516904 http://dx.doi.org/10.1039/c9ra02950h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Makhmudiyarova, Nataliya N.
Ishmukhametova, Irina R.
Dzhemileva, Lilya U.
Tyumkina, Tatyana V.
D'yakonov, Vladimir A.
Ibragimov, Askhat G.
Dzhemilev, Usein M.
Synthesis and anticancer activity novel dimeric azatriperoxides
title Synthesis and anticancer activity novel dimeric azatriperoxides
title_full Synthesis and anticancer activity novel dimeric azatriperoxides
title_fullStr Synthesis and anticancer activity novel dimeric azatriperoxides
title_full_unstemmed Synthesis and anticancer activity novel dimeric azatriperoxides
title_short Synthesis and anticancer activity novel dimeric azatriperoxides
title_sort synthesis and anticancer activity novel dimeric azatriperoxides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064891/
https://www.ncbi.nlm.nih.gov/pubmed/35516904
http://dx.doi.org/10.1039/c9ra02950h
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