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Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10

Heterozygous mutations in BMPR2 (bone morphogenetic protein (BMP) receptor type II) cause pulmonary arterial hypertension. BMPRII is a receptor for over 15 BMP ligands, but why BMPR2 mutations cause lung-specific pathology is unknown. To elucidate the molecular basis of BMP:BMPRII interactions, we r...

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Detalles Bibliográficos
Autores principales:	Guo, Jingxu, Liu, Bin, Thorikay, Midory, Yu, Minmin, Li, Xiaoyan, Tong, Zhen, Salmon, Richard M., Read, Randy J., ten Dijke, Peter, Morrell, Nicholas W., Li, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9064986/ https://www.ncbi.nlm.nih.gov/pubmed/35504921 http://dx.doi.org/10.1038/s41467-022-30111-2

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