Cargando…

Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism

Human neurodegenerative disorders often exhibit similar pathologies, suggesting a shared aetiology. Key pathological features of Parkinson’s disease (PD) are also observed in other neurodegenerative diseases. Pantothenate Kinase-Associated Neurodegeneration (PKAN) is caused by mutations in the human...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yunpeng, Wan, Zhihui, Tang, Yinglu, Xu, Junxuan, Laboret, Bretton, Nallamothu, Sree, Yang, Chenyu, Liu, Boxiang, Lu, Rongze Olivia, Lu, Bingwei, Feng, Juan, Cao, Jing, Hayflick, Susan, Wu, Zhihao, Zhou, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065001/ https://www.ncbi.nlm.nih.gov/pubmed/35504872 http://dx.doi.org/10.1038/s41467-022-30178-x

Ejemplares similares

Improving acetyl-CoA biosynthesis in Saccharomyces cerevisiae via the overexpression of pantothenate kinase and PDH bypass
por: Liu, Wenshan, et al.
Publicado: (2017)

Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
por: Kudo, Hirotaka, et al.
Publicado: (2023)

Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency
por: Di Meo, Ivano, et al.
Publicado: (2017)

Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets
por: de Vries, Laura E., et al.
Publicado: (2021)

Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration
por: Siudeja, Katarzyna, et al.
Publicado: (2011)

Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway
por: Olzhausen, Judith, et al.
Publicado: (2021)

Targeting PINK1 and MQC in brain tumors
por: Lee, Kyu-Sun, et al.
Publicado: (2014)

The effect of tumour growth on liver pantothenate, CoA, and fatty acid synthetase activity in the mouse.
por: McAllister, R. A., et al.
Publicado: (1988)

Germline Deletion of Pantothenate Kinases 1 and 2 Reveals the Key Roles for CoA in Postnatal Metabolism
por: Garcia, Matthew, et al.
Publicado: (2012)

Reduction of Protein Translation and Activation of Autophagy Protect against PINK1 Pathogenesis in Drosophila melanogaster
por: Liu, Song, et al.
Publicado: (2010)

Acetyl-CoA Carboxylases and Diseases
por: Wang, Yu, et al.
Publicado: (2022)

ACETYL-COA SYNTHETASE REGULATES HISTONE ACETYLATION AND HIPPOCAMPAL MEMORY
por: Mews, Philipp, et al.
Publicado: (2017)

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
por: Bradshaw, Patrick C.
Publicado: (2021)

Chemical Genetics of Acetyl-CoA Carboxylases
por: Zu, Xuyu, et al.
Publicado: (2013)

Compartmentalization of Mammalian Pantothenate Kinases
por: Alfonso-Pecchio, Adolfo, et al.
Publicado: (2012)

Pantothenate kinase-associated neurodegeneration
por: Hundallah, Khalid, et al.
Publicado: (2017)

Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
por: Lee, Kyu-Sun, et al.
Publicado: (2013)

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
por: Tjhin, Erick T., et al.
Publicado: (2018)

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses
por: Houston, Ryan, et al.
Publicado: (2020)

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
por: Huang, Yunpeng, et al.
Publicado: (2014)

Acetyl-CoA and the Regulation of Metabolism: Mechanisms and Consequences
por: Shi, Lei, et al.
Publicado: (2015)

The dynamic organization of fungal acetyl-CoA carboxylase
por: Hunkeler, Moritz, et al.
Publicado: (2016)

Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model
por: Brunetti, Dario, et al.
Publicado: (2012)

Intracellular Citrate/acetyl-CoA flux and endoplasmic reticulum acetylation: Connectivity is the answer
por: Fernandez-Fuente, Gonzalo, et al.
Publicado: (2022)

The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation
por: Nair, Sethu C., et al.
Publicado: (2023)

Modulation of plant acetyl-CoA synthetase activity by post-translational lysine acetylation
por: Sofeo, Naazneen, et al.
Publicado: (2023)

THE EFFECTS OF PANTOTHENIC ACID ON RESPIRATORY ACTIVITY
por: Pratt, Ernest F., et al.
Publicado: (1939)

Genetic mutation spectrum of pantothenate kinase-associated neurodegeneration expanded by breakpoint sequencing in pantothenate kinase 2 gene
por: Yang, Dahae, et al.
Publicado: (2022)

Molecular Cloning and Analysis of an Acetyl-CoA C-acetyltransferase Gene (EkAACT) from Euphorbia kansui Liou
por: Wang, Meng, et al.
Publicado: (2022)

N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae
por: Varland, Sylvia, et al.
Publicado: (2018)

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk
por: Dieterich, Inca A., et al.
Publicado: (2019)

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression
por: Lozoya, Oswaldo A, et al.
Publicado: (2019)

Role of Motif III in Catalysis by Acetyl-CoA Synthetase
por: Ingram-Smith, Cheryl, et al.
Publicado: (2012)

Acetyl-CoA-directed gene transcription in cancer cells
por: Martínez-Reyes, Inmaculada, et al.
Publicado: (2018)

Older Than Genes: The Acetyl CoA Pathway and Origins
por: Martin, William F.
Publicado: (2020)

Dynamics of the Degradation of Acetyl-CoA Carboxylase Herbicides in Vegetables
por: Jursík, Miroslav, et al.
Publicado: (2021)

Targeting acetyl-CoA carboxylase 1 for cancer therapy
por: Yu, Yong, et al.
Publicado: (2023)

Gaining access to acetyl-CoA by peroxisomal surface display
por: Perrot, Thomas, et al.
Publicado: (2023)

Enzymatic characterization of two acetyl-CoA synthetase genes from Populus trichocarpa
por: Cao, Shan, et al.
Publicado: (2016)

The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma
por: Li, Kun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_56orert03333r8qvgpbntvdag7