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Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics

Multi-receptor targeting has been proposed as a promising strategy for the development of opioid analgesics with fewer side effects. Cebranopadol and AT-121 are prototypical bifunctional ligands targeting the nociceptin/orphanin FQ peptide receptor (NOP) and µ-opioid receptor (MOP) that elicit poten...

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Detalles Bibliográficos
Autores principales:	Dasgupta, Pooja, Mann, Anika, Polgar, Willma E., Reinscheid, Rainer K., Zaveri, Nurulain T., Schulz, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065038/ https://www.ncbi.nlm.nih.gov/pubmed/35504962 http://dx.doi.org/10.1038/s41598-022-11189-6

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