IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

IRF4 is a master regulator of immunity and is also frequently overexpressed in mature lymphoid neoplasms. Here, we demonstrate the oncogenicity of IRF4 in vivo, its potential effects on T-cell development and clonal evolution using a zebrafish model. IRF4-transgenic zebrafish develop aggressive tumo...

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Detalles Bibliográficos
Autores principales: Amanda, Stella, Tan, Tze King, Ong, Jolynn Zu Lin, Theardy, Madelaine Skolastika, Wong, Regina Wan Ju, Huang, Xiao Zi, Ali, Muhammad Zulfaqar, Li, Yan, Gong, Zhiyuan, Inagaki, Hiroshi, Foo, Ee Yong, Pang, Brendan, Tan, Soo Yong, Iida, Shinsuke, Sanda, Takaomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065160/
https://www.ncbi.nlm.nih.gov/pubmed/35504924
http://dx.doi.org/10.1038/s41467-022-30053-9

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