Cargando…

mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma

Background: Hepatocellular Carcinoma (HCC) is a major form of liver cancer and a leading cause of cancer-related death worldwide. New insights into HCC pathobiology and mechanism of drug actions are urgently needed to improve patient outcomes. HCC undergoes metabolic reprogramming of glucose metabol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hong, Su, Xiaoyang, Burley, Stephen K., Zheng, X.F. Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065186/ https://www.ncbi.nlm.nih.gov/pubmed/35547764 http://dx.doi.org/10.7150/thno.72581

Ejemplares similares

NEAT1 and Paraspeckles in Cancer Development and Chemoresistance
por: Pisani, Gabriel, et al.
Publicado: (2020)

A toolkit for the identification of NEAT1_2/paraspeckle modulators
por: An, Haiyan, et al.
Publicado: (2022)

Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures
por: Shen, Wen, et al.
Publicado: (2014)

NEAT1 and paraspeckles in neurodegenerative diseases: A missing lnc found?
por: An, Haiyan, et al.
Publicado: (2018)

MLXIPL promotes the migration, invasion, and glycolysis of hepatocellular carcinoma cells by phosphorylation of mTOR
por: Chang, Xiaowei, et al.
Publicado: (2023)

Highly Ordered Spatial Organization of the Structural Long Noncoding NEAT1 RNAs within Paraspeckle Nuclear Bodies
por: Souquere, Sylvie, et al.
Publicado: (2010)

Decreased Expression of MPC2 Contributes to Aerobic Glycolysis and Colorectal Cancer Proliferation by Activating mTOR Pathway
por: Kuerbanjiang, Manzila, et al.
Publicado: (2021)

S100A10 Accelerates Aerobic Glycolysis and Malignant Growth by Activating mTOR-Signaling Pathway in Gastric Cancer
por: Li, Yan, et al.
Publicado: (2020)

STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer
por: Wu, Fan, et al.
Publicado: (2018)

Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1
por: Barra, Jasmine, et al.
Publicado: (2020)

Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia
por: Godet, Anne-Claire, et al.
Publicado: (2022)

Functional dissection of NEAT1 using genome editing reveals substantial localization of the NEAT1_1 isoform outside paraspeckles
por: Li, Ruohan, et al.
Publicado: (2017)

Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice
por: Isobe, Momo, et al.
Publicado: (2020)

Targeting mTOR and Glycolysis in HER2-Positive Breast Cancer
por: Holloway, Ryan W., et al.
Publicado: (2021)

NEAT1 Long Noncoding RNA and Paraspeckle Bodies Modulate HIV-1 Posttranscriptional Expression
por: Zhang, Quan, et al.
Publicado: (2013)

Matrix stiffness-sensitive long noncoding RNA NEAT1 seeded paraspeckles in cancer cells
por: Todorovski, Vanja, et al.
Publicado: (2020)

Paraspeckle nuclear bodies—useful uselessness?
por: Nakagawa, Shinichi, et al.
Publicado: (2012)

The role of long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) in chronic periodontitis progression
por: Zhang, Lei, et al.
Publicado: (2022)

The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention
por: Liu, Caizhi, et al.
Publicado: (2022)

Glycolysis-related biomarker TCIRG1 participates in regulation of renal cell carcinoma progression and tumor immune microenvironment by affecting aerobic glycolysis and AKT/mTOR signaling pathway
por: Di, Sichen, et al.
Publicado: (2023)

Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles
por: Major, Andrew T., et al.
Publicado: (2015)

LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?
por: Taiana, Elisa, et al.
Publicado: (2020)

Species-specific formation of paraspeckles in intestinal epithelium revealed by characterization of NEAT1 in naked mole-rat
por: Yamada, Akihiro, et al.
Publicado: (2022)

Metformin prevents PFKFB3-related aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts by regulating AMPK/mTOR pathway
por: Tang, Ci-Jun, et al.
Publicado: (2021)

The mTOR inhibitor AZD8055 inhibits proliferation and glycolysis in cervical cancer cells
por: LI, SHAORU, et al.
Publicado: (2013)

The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization
por: Beeharry, Yasnee, et al.
Publicado: (2018)

The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells
por: Zeng, Chengwu, et al.
Publicado: (2018)

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
por: Choudhry, H, et al.
Publicado: (2015)

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells
por: Woo, Yu Mi, et al.
Publicado: (2015)

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
por: Weng, Mei-lin, et al.
Publicado: (2020)

PBRM1 deficiency oncogenic addiction is associated with activated AKT–mTOR signalling and aerobic glycolysis in clear cell renal cell carcinoma cells
por: Tang, Yu, et al.
Publicado: (2022)

The nuclear import of ribosomal proteins is regulated by mTOR
por: Kazyken, Dubek, et al.
Publicado: (2014)

ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway
por: Huang, Wen-Kuan, et al.
Publicado: (2021)

Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma
por: Ferrín, Gustavo, et al.
Publicado: (2020)

Paraspeckles: nuclear bodies built on long noncoding RNA
por: Bond, Charles S., et al.
Publicado: (2009)

Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice
por: Nakagawa, Shinichi, et al.
Publicado: (2011)

Erratum: Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
por: Choudhry, H, et al.
Publicado: (2015)

The immunoregulatory protein B7-H3 promotes aerobic glycolysis in oral squamous carcinoma via PI3K/Akt/mTOR pathway
por: Li, Zhangao, et al.
Publicado: (2019)

LncRNA‐HOTAIRM1 promotes aerobic glycolysis and proliferation in osteosarcoma via the miR‐664b‐3p/Rheb/mTOR pathway
por: Yu, Xuecheng, et al.
Publicado: (2023)

Neat1 regulates oxidized low-density lipoprotein-induced inflammation and lipid uptake in macrophages via paraspeckle formation
por: Huang-Fu, Ning, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mtv18viqq35cl1eoqdd6k5qpo1