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Inflammasomes in Cancer Progression and Anti-Tumor Immunity

The inflammasomes are critical regulators of innate immunity, inflammation and cell death and have emerged as important regulators of cancer development and control. Inflammasomes are assembled by pattern recognition receptors (PRR) following the sensing of microbial- or danger-associated molecular...

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Autores principales: Lillo, Sebastian, Saleh, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065266/
https://www.ncbi.nlm.nih.gov/pubmed/35517498
http://dx.doi.org/10.3389/fcell.2022.839041
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author Lillo, Sebastian
Saleh, Maya
author_facet Lillo, Sebastian
Saleh, Maya
author_sort Lillo, Sebastian
collection PubMed
description The inflammasomes are critical regulators of innate immunity, inflammation and cell death and have emerged as important regulators of cancer development and control. Inflammasomes are assembled by pattern recognition receptors (PRR) following the sensing of microbial- or danger-associated molecular patterns (MAMPs/DAMPs) and elicit inflammation through the oligomerization and activation of inflammatory caspases. These cysteinyl-aspartate proteases cleave the proinflammatory cytokines IL-1β and IL-18 into their biologically active mature form. The roles of the inflammasomes and associated pro-inflammatory cytokines vary greatly depending on the cancer type. Here we discuss recent studies highlighting contrasting roles of the inflammasome pathway in curbing versus promoting tumorigenesis. On one hand, the inflammasomes participate in stimulating anti-tumor immunity, but they have also been shown to contribute to immunosuppression or to directly promote tumor cell survival, proliferation, and metastasis. A better understanding of inflammasome functions in different cancers is thus critical for the design of novel cancer immunotherapies.
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spelling pubmed-90652662022-05-04 Inflammasomes in Cancer Progression and Anti-Tumor Immunity Lillo, Sebastian Saleh, Maya Front Cell Dev Biol Cell and Developmental Biology The inflammasomes are critical regulators of innate immunity, inflammation and cell death and have emerged as important regulators of cancer development and control. Inflammasomes are assembled by pattern recognition receptors (PRR) following the sensing of microbial- or danger-associated molecular patterns (MAMPs/DAMPs) and elicit inflammation through the oligomerization and activation of inflammatory caspases. These cysteinyl-aspartate proteases cleave the proinflammatory cytokines IL-1β and IL-18 into their biologically active mature form. The roles of the inflammasomes and associated pro-inflammatory cytokines vary greatly depending on the cancer type. Here we discuss recent studies highlighting contrasting roles of the inflammasome pathway in curbing versus promoting tumorigenesis. On one hand, the inflammasomes participate in stimulating anti-tumor immunity, but they have also been shown to contribute to immunosuppression or to directly promote tumor cell survival, proliferation, and metastasis. A better understanding of inflammasome functions in different cancers is thus critical for the design of novel cancer immunotherapies. Frontiers Media S.A. 2022-04-20 /pmc/articles/PMC9065266/ /pubmed/35517498 http://dx.doi.org/10.3389/fcell.2022.839041 Text en Copyright © 2022 Lillo and Saleh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Lillo, Sebastian
Saleh, Maya
Inflammasomes in Cancer Progression and Anti-Tumor Immunity
title Inflammasomes in Cancer Progression and Anti-Tumor Immunity
title_full Inflammasomes in Cancer Progression and Anti-Tumor Immunity
title_fullStr Inflammasomes in Cancer Progression and Anti-Tumor Immunity
title_full_unstemmed Inflammasomes in Cancer Progression and Anti-Tumor Immunity
title_short Inflammasomes in Cancer Progression and Anti-Tumor Immunity
title_sort inflammasomes in cancer progression and anti-tumor immunity
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065266/
https://www.ncbi.nlm.nih.gov/pubmed/35517498
http://dx.doi.org/10.3389/fcell.2022.839041
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