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Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids

Molecularly imprinted polymers (MIPs) prepared using conventional functional monomers exhibit poor specific extraction of scopolamine from tropane alkaloids, which hinders their application in separation and purification. In this paper, a novel molecularly imprinted polymer (MIP) was prepared by pre...

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Detalles Bibliográficos
Autores principales: Zuo, Jie, Zhang, Xingyuan, Li, Xinyu, Li, Zhiwei, Li, Zongren, Li, Honghong, Zhang, Wencheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065296/
https://www.ncbi.nlm.nih.gov/pubmed/35519365
http://dx.doi.org/10.1039/c9ra03542g
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author Zuo, Jie
Zhang, Xingyuan
Li, Xinyu
Li, Zhiwei
Li, Zongren
Li, Honghong
Zhang, Wencheng
author_facet Zuo, Jie
Zhang, Xingyuan
Li, Xinyu
Li, Zhiwei
Li, Zongren
Li, Honghong
Zhang, Wencheng
author_sort Zuo, Jie
collection PubMed
description Molecularly imprinted polymers (MIPs) prepared using conventional functional monomers exhibit poor specific extraction of scopolamine from tropane alkaloids, which hinders their application in separation and purification. In this paper, a novel molecularly imprinted polymer (MIP) was prepared by precipitation polymerization using scopolamine as the template, monoethyl fumarate (MFMA) as a functional monomer, and ethylene dimethacrylate (EGDMA) as a cross-linker. The advantages of the supercritical fluid technology for the removal of the template were verified by comparing the efficiency of the swelling method and the Soxhlet extraction method. The prepared MFMA-based MIPs (MFMA-MIPs) showed a high adsorption capacity (49.75 mg g(−1)) and high selectivity toward scopolamine with a selectivity coefficient of 3.5. (1)H NMR spectroscopy was performed to demonstrate the interactions between the two functional groups of the functional monomer and the template. Lastly, MFMA-MIPs were used as solid phase extraction (SPE) sorbents for scopolamine analysis. It was found that 97.0–107.0% of the template had been extracted using the SPE column from the complex of scopolamine, atropine and anisodamine. The mean recoveries of scopolamine from plant samples were 96.0–106.0% using the established method, which showed a good linearity in the range of 8.0–4.0 × 10(4) μg L(−1). The results showed that MFMA-MIPs could be applied for the separation of scopolamine from tropane alkaloids.
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spelling pubmed-90652962022-05-04 Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids Zuo, Jie Zhang, Xingyuan Li, Xinyu Li, Zhiwei Li, Zongren Li, Honghong Zhang, Wencheng RSC Adv Chemistry Molecularly imprinted polymers (MIPs) prepared using conventional functional monomers exhibit poor specific extraction of scopolamine from tropane alkaloids, which hinders their application in separation and purification. In this paper, a novel molecularly imprinted polymer (MIP) was prepared by precipitation polymerization using scopolamine as the template, monoethyl fumarate (MFMA) as a functional monomer, and ethylene dimethacrylate (EGDMA) as a cross-linker. The advantages of the supercritical fluid technology for the removal of the template were verified by comparing the efficiency of the swelling method and the Soxhlet extraction method. The prepared MFMA-based MIPs (MFMA-MIPs) showed a high adsorption capacity (49.75 mg g(−1)) and high selectivity toward scopolamine with a selectivity coefficient of 3.5. (1)H NMR spectroscopy was performed to demonstrate the interactions between the two functional groups of the functional monomer and the template. Lastly, MFMA-MIPs were used as solid phase extraction (SPE) sorbents for scopolamine analysis. It was found that 97.0–107.0% of the template had been extracted using the SPE column from the complex of scopolamine, atropine and anisodamine. The mean recoveries of scopolamine from plant samples were 96.0–106.0% using the established method, which showed a good linearity in the range of 8.0–4.0 × 10(4) μg L(−1). The results showed that MFMA-MIPs could be applied for the separation of scopolamine from tropane alkaloids. The Royal Society of Chemistry 2019-06-25 /pmc/articles/PMC9065296/ /pubmed/35519365 http://dx.doi.org/10.1039/c9ra03542g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zuo, Jie
Zhang, Xingyuan
Li, Xinyu
Li, Zhiwei
Li, Zongren
Li, Honghong
Zhang, Wencheng
Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids
title Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids
title_full Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids
title_fullStr Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids
title_full_unstemmed Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids
title_short Preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids
title_sort preparation of monoethyl fumarate-based molecularly imprinted polymers and their application as a solid-phase extraction sorbent for the separation of scopolamine from tropane alkaloids
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065296/
https://www.ncbi.nlm.nih.gov/pubmed/35519365
http://dx.doi.org/10.1039/c9ra03542g
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