Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation

Blastic plasmacytoid dendritic cell neoplasm usually presents as skin lesions. Diagnostic error occurs when it primarily presents in leukemic phase without skin involvement. Triad of CD4, CD56 and CD123 immunophenotype expression is essential to avoid misdiagnosis of this rare hematological malignan...

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Detalles Bibliográficos
Autores principales: Alam, Hareem, Saeed, Nabiha, Rashid, Anila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065302/
https://www.ncbi.nlm.nih.gov/pubmed/35518189
http://dx.doi.org/10.1016/j.lrr.2022.100317
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author Alam, Hareem
Saeed, Nabiha
Rashid, Anila
author_facet Alam, Hareem
Saeed, Nabiha
Rashid, Anila
author_sort Alam, Hareem
collection PubMed
description Blastic plasmacytoid dendritic cell neoplasm usually presents as skin lesions. Diagnostic error occurs when it primarily presents in leukemic phase without skin involvement. Triad of CD4, CD56 and CD123 immunophenotype expression is essential to avoid misdiagnosis of this rare hematological malignancy. Here we describe a patient who presented in overt leukemic phase of BPDCN highlighting diagnostic challenges encountered that resulted in delayed diagnosis and poor outcome.
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spelling pubmed-90653022022-05-04 Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation Alam, Hareem Saeed, Nabiha Rashid, Anila Leuk Res Rep Case Report Blastic plasmacytoid dendritic cell neoplasm usually presents as skin lesions. Diagnostic error occurs when it primarily presents in leukemic phase without skin involvement. Triad of CD4, CD56 and CD123 immunophenotype expression is essential to avoid misdiagnosis of this rare hematological malignancy. Here we describe a patient who presented in overt leukemic phase of BPDCN highlighting diagnostic challenges encountered that resulted in delayed diagnosis and poor outcome. Elsevier 2022-04-25 /pmc/articles/PMC9065302/ /pubmed/35518189 http://dx.doi.org/10.1016/j.lrr.2022.100317 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Alam, Hareem
Saeed, Nabiha
Rashid, Anila
Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation
title Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation
title_full Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation
title_fullStr Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation
title_full_unstemmed Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation
title_short Indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation
title_sort indispensable role of immunophenotyping in diagnosing leukemic phase of blastic plasmacytoid dendritic cell neoplasm without cutaneous manifestation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065302/
https://www.ncbi.nlm.nih.gov/pubmed/35518189
http://dx.doi.org/10.1016/j.lrr.2022.100317
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AT rashidanila indispensableroleofimmunophenotypingindiagnosingleukemicphaseofblasticplasmacytoiddendriticcellneoplasmwithoutcutaneousmanifestation

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