Mitigating analyte to stable isotope labelled internal standard cross-signal contribution in quantitative liquid chromatography-tandem mass spectrometry

BACKGROUND: Utilising stable isotope labelled internal standards (SIL-IS) in quantitative LC-MS/MS drug analysis is the most widely used approach to normalise for variability during sample quantification processes. However, compounds containing atoms such as Sulphur, Chlorine or Bromine, could poten...

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Detalles Bibliográficos
Autores principales: Radovanovic, Mirjana, Jones, Graham, Day, Richard O., Galettis, Peter, Norris, Ross L.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065310/
https://www.ncbi.nlm.nih.gov/pubmed/35520954
http://dx.doi.org/10.1016/j.jmsacl.2022.04.002

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