Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways

The deacetylase HDAC6 has tandem catalytic domains and a zinc finger domain (ZnF) binding ubiquitin (Ub). While the catalytic domain has an antiviral effect, the ZnF facilitates influenza A virus (IAV) infection and cellular stress responses. By recruiting Ub via the ZnF, HDAC6 promotes the formatio...

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Detalles Bibliográficos
Autores principales: Wang, Longlong, Moreira, Etori Aguiar, Kempf, Georg, Miyake, Yasuyuki, Oliveira Esteves, Blandina I., Fahmi, Amal, Schaefer, Jonas V., Dreier, Birgit, Yamauchi, Yohei, Alves, Marco P., Plückthun, Andreas, Matthias, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065369/
https://www.ncbi.nlm.nih.gov/pubmed/35476995
http://dx.doi.org/10.1016/j.celrep.2022.110736

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