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Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial
Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine. Oxidative stress and inflammation play a major role in IBS. Considering the antioxidant properties of ellagic acid (EA), this study was designed to evaluate the effect of EA on oxidative stress index, inflammatory...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Clinical Nutrition
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065395/ https://www.ncbi.nlm.nih.gov/pubmed/35558999 http://dx.doi.org/10.7762/cnr.2022.11.2.98 |
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author | Mirzaie, Zahra Bastani, Ali Haji-Aghamohammadi, Ali Akbar Rashidi Nooshabadi, Mohammadreza Ahadinezhad, Bahman Khadem Haghighian, Hossein |
author_facet | Mirzaie, Zahra Bastani, Ali Haji-Aghamohammadi, Ali Akbar Rashidi Nooshabadi, Mohammadreza Ahadinezhad, Bahman Khadem Haghighian, Hossein |
author_sort | Mirzaie, Zahra |
collection | PubMed |
description | Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine. Oxidative stress and inflammation play a major role in IBS. Considering the antioxidant properties of ellagic acid (EA), this study was designed to evaluate the effect of EA on oxidative stress index, inflammatory markers, and quality of life in patients with IBS. This research was conducted as a randomized, double-blind, placebo-controlled clinical trial; 44 patients with IBS were recruited. Patients who met the inclusion criteria were randomly allocated to consume a capsule containing 180 mg of EA per day (n = 22) or a placebo (n = 22) for 8 weeks. Serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), and interleukin-6 (IL-6) were measured at the beginning and the end of the study. Also, quality of life was assessed using a self-report questionnaire for IBS patients (IBS-QOL). At the end of the study, we saw a significant decrease and increase in the MDA and TAC in the intervention group, respectively (p < 0.05). Also, EA consumption reduced CRP and IL-6 levels, and these changes were significant in comparison with placebo group changes (p < 0.05). The overall score of IBS-QOL significantly decreased, and quality of life was increased (p < 0.05), but there were no significant changes in the placebo group. According to these findings, receiving polyphenols, such as EA, may help maintain intestinal health by modulating inflammation and oxidative stress and ultimately improving the quality of life in IBS patients. TRIAL REGISTRATION: Iranian Registry of Clinical Trials Identifier: IRCT20141025019669N11 |
format | Online Article Text |
id | pubmed-9065395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society of Clinical Nutrition |
record_format | MEDLINE/PubMed |
spelling | pubmed-90653952022-05-11 Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial Mirzaie, Zahra Bastani, Ali Haji-Aghamohammadi, Ali Akbar Rashidi Nooshabadi, Mohammadreza Ahadinezhad, Bahman Khadem Haghighian, Hossein Clin Nutr Res Original Article Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine. Oxidative stress and inflammation play a major role in IBS. Considering the antioxidant properties of ellagic acid (EA), this study was designed to evaluate the effect of EA on oxidative stress index, inflammatory markers, and quality of life in patients with IBS. This research was conducted as a randomized, double-blind, placebo-controlled clinical trial; 44 patients with IBS were recruited. Patients who met the inclusion criteria were randomly allocated to consume a capsule containing 180 mg of EA per day (n = 22) or a placebo (n = 22) for 8 weeks. Serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), and interleukin-6 (IL-6) were measured at the beginning and the end of the study. Also, quality of life was assessed using a self-report questionnaire for IBS patients (IBS-QOL). At the end of the study, we saw a significant decrease and increase in the MDA and TAC in the intervention group, respectively (p < 0.05). Also, EA consumption reduced CRP and IL-6 levels, and these changes were significant in comparison with placebo group changes (p < 0.05). The overall score of IBS-QOL significantly decreased, and quality of life was increased (p < 0.05), but there were no significant changes in the placebo group. According to these findings, receiving polyphenols, such as EA, may help maintain intestinal health by modulating inflammation and oxidative stress and ultimately improving the quality of life in IBS patients. TRIAL REGISTRATION: Iranian Registry of Clinical Trials Identifier: IRCT20141025019669N11 Korean Society of Clinical Nutrition 2022-04-27 /pmc/articles/PMC9065395/ /pubmed/35558999 http://dx.doi.org/10.7762/cnr.2022.11.2.98 Text en Copyright © 2022. The Korean Society of Clinical Nutrition https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mirzaie, Zahra Bastani, Ali Haji-Aghamohammadi, Ali Akbar Rashidi Nooshabadi, Mohammadreza Ahadinezhad, Bahman Khadem Haghighian, Hossein Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial |
title | Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial |
title_full | Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial |
title_fullStr | Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial |
title_full_unstemmed | Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial |
title_short | Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial |
title_sort | effects of ellagic acid on oxidative stress index, inflammatory markers and quality of life in patients with irritable bowel syndrome: randomized double-blind clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065395/ https://www.ncbi.nlm.nih.gov/pubmed/35558999 http://dx.doi.org/10.7762/cnr.2022.11.2.98 |
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