Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality

This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median ef...

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Detalles Bibliográficos
Autores principales: Okumu, Mitchel Otieno, Mbaria, James Mucunu, Gikunju, Joseph Kangangi, Mbuthia, Paul Gichohi, Madadi, Vincent Odongo, Ochola, Francis Okumu, Maloba, Kenneth Narotso, Nderitu, Joseph Gichuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Clinical studies, antivenoms and epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065424/
https://www.ncbi.nlm.nih.gov/pubmed/35518711
http://dx.doi.org/10.1016/j.toxcx.2022.100124
Descripción
Sumario:This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).

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