Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality

This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median ef...

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Detalles Bibliográficos
Autores principales: Okumu, Mitchel Otieno, Mbaria, James Mucunu, Gikunju, Joseph Kangangi, Mbuthia, Paul Gichohi, Madadi, Vincent Odongo, Ochola, Francis Okumu, Maloba, Kenneth Narotso, Nderitu, Joseph Gichuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Clinical studies, antivenoms and epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065424/
https://www.ncbi.nlm.nih.gov/pubmed/35518711
http://dx.doi.org/10.1016/j.toxcx.2022.100124
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author Okumu, Mitchel Otieno
Mbaria, James Mucunu
Gikunju, Joseph Kangangi
Mbuthia, Paul Gichohi
Madadi, Vincent Odongo
Ochola, Francis Okumu
Maloba, Kenneth Narotso
Nderitu, Joseph Gichuki
author_facet Okumu, Mitchel Otieno
Mbaria, James Mucunu
Gikunju, Joseph Kangangi
Mbuthia, Paul Gichohi
Madadi, Vincent Odongo
Ochola, Francis Okumu
Maloba, Kenneth Narotso
Nderitu, Joseph Gichuki
author_sort Okumu, Mitchel Otieno
collection PubMed
description This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).
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spelling pubmed-90654242022-05-04 Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality Okumu, Mitchel Otieno Mbaria, James Mucunu Gikunju, Joseph Kangangi Mbuthia, Paul Gichohi Madadi, Vincent Odongo Ochola, Francis Okumu Maloba, Kenneth Narotso Nderitu, Joseph Gichuki Toxicon X Clinical studies, antivenoms and epidemiology This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV). Elsevier 2022-04-27 /pmc/articles/PMC9065424/ /pubmed/35518711 http://dx.doi.org/10.1016/j.toxcx.2022.100124 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Clinical studies, antivenoms and epidemiology
Okumu, Mitchel Otieno
Mbaria, James Mucunu
Gikunju, Joseph Kangangi
Mbuthia, Paul Gichohi
Madadi, Vincent Odongo
Ochola, Francis Okumu
Maloba, Kenneth Narotso
Nderitu, Joseph Gichuki
Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality
title Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality
title_full Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality
title_fullStr Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality
title_full_unstemmed Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality
title_short Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality
title_sort preclinical efficacy testing of three antivenoms against naja ashei venom-induced lethality
topic Clinical studies, antivenoms and epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065424/
https://www.ncbi.nlm.nih.gov/pubmed/35518711
http://dx.doi.org/10.1016/j.toxcx.2022.100124
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