Cargando…

Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality

This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okumu, Mitchel Otieno, Mbaria, James Mucunu, Gikunju, Joseph Kangangi, Mbuthia, Paul Gichohi, Madadi, Vincent Odongo, Ochola, Francis Okumu, Maloba, Kenneth Narotso, Nderitu, Joseph Gichuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Clinical studies, antivenoms and epidemiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065424/ https://www.ncbi.nlm.nih.gov/pubmed/35518711 http://dx.doi.org/10.1016/j.toxcx.2022.100124

Ejemplares similares

Enzymatic activity and brine shrimp lethality of venom from the large brown spitting cobra (Naja ashei) and its neutralization by antivenom
por: Okumu, Mitchel Otieno, et al.
Publicado: (2020)

Artemia salina as an animal model for the preliminary evaluation of snake venom-induced toxicity
por: Okumu, Mitchel Otieno, et al.
Publicado: (2021)

Epidemiology of snake bites in selected areas of Kenya
por: Ochola, Francis Okumu, et al.
Publicado: (2018)

Revered but Poorly Understood: A Case Report of Dendroaspis polylepis (Black Mamba) Envenomation in Watamu, Malindi Kenya, and a Review of the Literature
por: Erulu, Valentine Eugene, et al.
Publicado: (2018)

Evaluation of lethality and cytotoxic effects induced by Naja ashei (large brown spitting cobra) venom and the envenomation-neutralizing efficacy of selected commercial antivenoms in Kenya
por: Manson, Ernest Z., et al.
Publicado: (2022)

First Look at the Venom of Naja ashei
por: Hus, Konrad Kamil, et al.
Publicado: (2018)

Management and cost of snakebite injuries at a teaching and referral hospital in Western Kenya
por: Okumu, Mitchel Otieno, et al.
Publicado: (2019)

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya
por: Mailu, James Kiamba, et al.
Publicado: (2020)

Different Research Approaches in Unraveling the Venom Proteome of Naja ashei
por: Hus, Konrad Kamil, et al.
Publicado: (2020)

Preliminary Phytochemical Composition and In Vitro Anthelmintic Activity of Aqueous and Ethanol Extracts of Olea africana against Mixed Gastrointestinal Worms in Dogs
por: Orengo, Kenneth Otieno, et al.
Publicado: (2022)

Antibacterial Activity of Venom from the Puff Adder (Bitis arietans), Egyptian Cobra (Naja haje), and Red Spitting Cobra (Naja pallida)
por: Okumu, Mitchel Otieno, et al.
Publicado: (2023)

Clinical effects of immunization, bleeding, and albumin-based fluid therapy in horses used as immunoglobulin source to produce a polyspecific antivenom (Echitab-plus-ICP) towards venoms of African snakes
por: Huertas, Rose Mary, et al.
Publicado: (2023)

The legislative and regulatory framework governing herbal medicine use and practice in Kenya: a review
por: Okumu, Mitchel Otieno, et al.
Publicado: (2017)

Antimicrobial Activity of Protein Fraction from Naja ashei Venom against Staphylococcus epidermidis
por: Bocian, Aleksandra, et al.
Publicado: (2020)

Effects of 3FTx Protein Fraction from Naja ashei Venom on the Model and Native Membranes: Recognition and Implications for the Mechanisms of Toxicity
por: Dyba, Barbara, et al.
Publicado: (2021)

Cytotoxicity of Venoms and Cytotoxins from Asiatic Cobras (Naja kaouthia, Naja sumatrana, Naja atra) and Neutralization by Antivenoms from Thailand, Vietnam, and Taiwan
por: Chong, Ho Phin, et al.
Publicado: (2022)

Multilevel Comparison of Indian Naja Venoms and Their Cross-Reactivity with Indian Polyvalent Antivenoms
por: Deka, Archana, et al.
Publicado: (2023)

Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning
por: Yang, Jie, et al.
Publicado: (2023)

In Vitro neurotoxicity and myotoxicity of Malaysian Naja sumatrana and Naja kaouthia venoms: Neutralization by monovalent and Neuro Polyvalent Antivenoms from Thailand
por: Zukifli, Nor Asyikin, et al.
Publicado: (2022)

An Examination of the Neutralization of In Vitro Toxicity of Chinese Cobra (Naja atra) Venom by Different Antivenoms
por: Liang, Qing, et al.
Publicado: (2020)

Geographic variation in the clinical features of Mohave rattlesnake (Crotalus scutulatus) envenomations reported to the North American Snakebite Registry
por: Greene, Spencer, et al.
Publicado: (2023)

Effect of Indian Polyvalent Antivenom in the Prevention and Reversal of Local Myotoxicity Induced by Common Cobra (Naja naja) Venom from Sri Lanka In Vitro
por: Madhushani, Umesha, et al.
Publicado: (2021)

Acute Poisonings at a Regional Referral Hospital in Western Kenya
por: Okumu, Mitchel Otieno, et al.
Publicado: (2018)

Venomics of the Enigmatic Andaman Cobra (Naja sagittifera) and the Preclinical Failure of Indian Antivenoms in Andaman and Nicobar Islands
por: Attarde, Saurabh, et al.
Publicado: (2021)

Analysis of the Necrosis-Inducing Components of the Venom of Naja atra and Assessment of the Neutralization Ability of Freeze-Dried Antivenom
por: Ho, Cheng-Hsuan, et al.
Publicado: (2021)

Development and Characterization of Anti-Naja ashei Three-Finger Toxins (3FTxs)-Specific Monoclonal Antibodies and Evaluation of Their In Vitro Inhibition Activity
por: Manson, Ernest Z., et al.
Publicado: (2022)

Biochemical and biological characterization of Naja kaouthia venom from North-East India and its neutralization by polyvalent antivenom
por: Das, Diganta, et al.
Publicado: (2013)

Assessing the Efficacy of Monovalent and Commercialized Antivenoms for Neutralizing Moroccan Cobra Naja haje Venom: A Comparative Study
por: Khourcha, Soukaina, et al.
Publicado: (2023)

Snake Venomics and Antivenomics of Cape Cobra (Naja nivea) from South Africa: Insights into Venom Toxicity and Cross-Neutralization Activity
por: Tan, Choo Hock, et al.
Publicado: (2022)

An in vitro potency assay using nicotinic acetylcholine receptor binding works well with antivenoms against Bungarus candidus and Naja naja
por: Ratanabanangkoon, Kavi, et al.
Publicado: (2018)

Identification of Immunoreactive Peptides of Toxins to Simultaneously Assess the Neutralization Potency of Antivenoms against Neurotoxicity and Cytotoxicity of Naja atra Venom
por: Liu, Bing-Sin, et al.
Publicado: (2017)

Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib)
por: Bittenbinder, Mátyás A., et al.
Publicado: (2018)

Analysis of the efficacy of Taiwanese freeze-dried neurotoxic antivenom against Naja kaouthia, Naja siamensis and Ophiophagus hannah through proteomics and animal model approaches
por: Liu, Chien-Chun, et al.
Publicado: (2017)

Studies on the ethnopharmacology, antimicrobial activity, and toxicity of Catha edulis (Vahl.) Endl., in Sprague Dawley rats
por: Githua, Kevin Kariuki, et al.
Publicado: (2022)

Differential Effects of Naja naja atra Venom on Immune Activity
por: Kou, Jian-Qun, et al.
Publicado: (2014)

The Venom of Indian Cobra (Naja Naja) in Certain Painful Conditions
por: Chopra, R. N., et al.
Publicado: (1940)

Pathogenesis of local necrosis induced by Naja atra venom: Assessment of the neutralization ability of Taiwanese freeze-dried neurotoxic antivenom in animal models
por: Liu, Chien-Chun, et al.
Publicado: (2020)

The Effect of Australian and Asian Commercial Antivenoms in Reversing the Post-Synaptic Neurotoxicity of O. hannah, N. naja and N. kaouthia Venoms In Vitro
por: Huynh, Tam M., et al.
Publicado: (2022)

Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom
por: Wang, Shu-Zhi, et al.
Publicado: (2018)

Antibacterial Activity of Isolated Immunodominant Proteins of Naja Naja (Oxiana) Venom
por: talebi mehrdar, Mahboobeh, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_or34b4bccsmlhl5h8rp3ojqaio