A novel multi-reaction microdroplet platform for rapid radiochemistry optimization

During the development of novel tracers for positron emission tomography (PET), the optimization of the synthesis is hindered by practical limitations on the number of experiments that can be performed per day. Here we present a microliter droplet chip that contains multiple sites (4 or 16) to perfo...

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Detalles Bibliográficos
Autores principales: Rios, Alejandra, Wang, Jia, Chao, Philip H., van Dam, R. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065505/
https://www.ncbi.nlm.nih.gov/pubmed/35514735
http://dx.doi.org/10.1039/c9ra03639c
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author Rios, Alejandra
Wang, Jia
Chao, Philip H.
van Dam, R. Michael
author_facet Rios, Alejandra
Wang, Jia
Chao, Philip H.
van Dam, R. Michael
author_sort Rios, Alejandra
collection PubMed
description During the development of novel tracers for positron emission tomography (PET), the optimization of the synthesis is hindered by practical limitations on the number of experiments that can be performed per day. Here we present a microliter droplet chip that contains multiple sites (4 or 16) to perform reactions simultaneously under the same or different conditions to accelerate radiosynthesis optimization.
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spelling pubmed-90655052022-05-04 A novel multi-reaction microdroplet platform for rapid radiochemistry optimization Rios, Alejandra Wang, Jia Chao, Philip H. van Dam, R. Michael RSC Adv Chemistry During the development of novel tracers for positron emission tomography (PET), the optimization of the synthesis is hindered by practical limitations on the number of experiments that can be performed per day. Here we present a microliter droplet chip that contains multiple sites (4 or 16) to perform reactions simultaneously under the same or different conditions to accelerate radiosynthesis optimization. The Royal Society of Chemistry 2019-07-01 /pmc/articles/PMC9065505/ /pubmed/35514735 http://dx.doi.org/10.1039/c9ra03639c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Rios, Alejandra
Wang, Jia
Chao, Philip H.
van Dam, R. Michael
A novel multi-reaction microdroplet platform for rapid radiochemistry optimization
title A novel multi-reaction microdroplet platform for rapid radiochemistry optimization
title_full A novel multi-reaction microdroplet platform for rapid radiochemistry optimization
title_fullStr A novel multi-reaction microdroplet platform for rapid radiochemistry optimization
title_full_unstemmed A novel multi-reaction microdroplet platform for rapid radiochemistry optimization
title_short A novel multi-reaction microdroplet platform for rapid radiochemistry optimization
title_sort novel multi-reaction microdroplet platform for rapid radiochemistry optimization
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065505/
https://www.ncbi.nlm.nih.gov/pubmed/35514735
http://dx.doi.org/10.1039/c9ra03639c
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