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The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases

N6-methyladenosine (m(6)A) is the most common and conserved internal eukaryotic mRNA modification. m(6)A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m(6)A-binding proteins recognise the m(6)A modificati...

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Autores principales: Sun, Jin, Cheng, Bokai, Su, Yongkang, Li, Man, Ma, Shouyuan, Zhang, Yan, Zhang, Anhang, Cai, Shuang, Bao, Qiligeer, Wang, Shuxia, Zhu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065606/
https://www.ncbi.nlm.nih.gov/pubmed/35518355
http://dx.doi.org/10.3389/fgene.2022.869950
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author Sun, Jin
Cheng, Bokai
Su, Yongkang
Li, Man
Ma, Shouyuan
Zhang, Yan
Zhang, Anhang
Cai, Shuang
Bao, Qiligeer
Wang, Shuxia
Zhu, Ping
author_facet Sun, Jin
Cheng, Bokai
Su, Yongkang
Li, Man
Ma, Shouyuan
Zhang, Yan
Zhang, Anhang
Cai, Shuang
Bao, Qiligeer
Wang, Shuxia
Zhu, Ping
author_sort Sun, Jin
collection PubMed
description N6-methyladenosine (m(6)A) is the most common and conserved internal eukaryotic mRNA modification. m(6)A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m(6)A-binding proteins recognise the m(6)A modification to regulate gene expression. Recent studies have shown that altered m(6)A levels and abnormal regulator expression are crucial in the ageing process and the occurrence of age-related diseases. In this review, we summarise some key findings in the field of m(6)A modification in the ageing process and age-related diseases, including cell senescence, autophagy, inflammation, oxidative stress, DNA damage, tumours, neurodegenerative diseases, diabetes, and cardiovascular diseases (CVDs). We focused on the biological function and potential molecular mechanisms of m(6)A RNA methylation in ageing and age-related disease progression. We believe that m(6)A modification may provide a new target for anti-ageing therapies.
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spelling pubmed-90656062022-05-04 The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases Sun, Jin Cheng, Bokai Su, Yongkang Li, Man Ma, Shouyuan Zhang, Yan Zhang, Anhang Cai, Shuang Bao, Qiligeer Wang, Shuxia Zhu, Ping Front Genet Genetics N6-methyladenosine (m(6)A) is the most common and conserved internal eukaryotic mRNA modification. m(6)A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m(6)A-binding proteins recognise the m(6)A modification to regulate gene expression. Recent studies have shown that altered m(6)A levels and abnormal regulator expression are crucial in the ageing process and the occurrence of age-related diseases. In this review, we summarise some key findings in the field of m(6)A modification in the ageing process and age-related diseases, including cell senescence, autophagy, inflammation, oxidative stress, DNA damage, tumours, neurodegenerative diseases, diabetes, and cardiovascular diseases (CVDs). We focused on the biological function and potential molecular mechanisms of m(6)A RNA methylation in ageing and age-related disease progression. We believe that m(6)A modification may provide a new target for anti-ageing therapies. Frontiers Media S.A. 2022-04-20 /pmc/articles/PMC9065606/ /pubmed/35518355 http://dx.doi.org/10.3389/fgene.2022.869950 Text en Copyright © 2022 Sun, Cheng, Su, Li, Ma, Zhang, Zhang, Cai, Bao, Wang and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Sun, Jin
Cheng, Bokai
Su, Yongkang
Li, Man
Ma, Shouyuan
Zhang, Yan
Zhang, Anhang
Cai, Shuang
Bao, Qiligeer
Wang, Shuxia
Zhu, Ping
The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases
title The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases
title_full The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases
title_fullStr The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases
title_full_unstemmed The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases
title_short The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases
title_sort potential role of m6a rna methylation in the aging process and aging-associated diseases
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065606/
https://www.ncbi.nlm.nih.gov/pubmed/35518355
http://dx.doi.org/10.3389/fgene.2022.869950
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