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Chimeric anti-GPC3 sFv-CD3ε receptor-modified T cells with IL7 co-expression for the treatment of solid tumors

Chimeric antigen receptor (CAR) T cells targeting glypican-3 (GPC3) demonstrated early signs of therapeutic efficacy to hepatocellular carcinoma patients with a risk of cytokine release syndrome (CRS). Several adoptive cell therapies (ACTs) with T cells using the natural T cell receptor (TCR) signal...

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Detalles Bibliográficos
Autores principales:	Sun, Yansha, Dong, Yiwei, Sun, Ruixin, Liu, Yifan, Wang, Yi, Luo, Hong, Shi, Bizhi, Jiang, Hua, Li, Zonghai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065615/ https://www.ncbi.nlm.nih.gov/pubmed/35572194 http://dx.doi.org/10.1016/j.omto.2022.04.003

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