Cargando…

Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors

Quantitative EEG (qEEG) delineates complex brain activities. Global field synchronization (GFS) is one multichannel EEG analysis that measures global functional connectivity through quantification of synchronization between signals. We hypothesized that preservation of global functional connectivity...

Descripción completa

Detalles Bibliográficos
Autores principales: Ho, Li-Ting, Serafico, Bess Ma. Fabinal, Hsu, Ching-En, Chen, Zhao-Wei, Lin, Tse-Yu, Lin, Chen, Lin, Lian-Yu, Lo, Men-Tzung, Chien, Kuo-Liong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065675/
https://www.ncbi.nlm.nih.gov/pubmed/35514330
http://dx.doi.org/10.3389/fphys.2022.866844
_version_ 1784699636608401408
author Ho, Li-Ting
Serafico, Bess Ma. Fabinal
Hsu, Ching-En
Chen, Zhao-Wei
Lin, Tse-Yu
Lin, Chen
Lin, Lian-Yu
Lo, Men-Tzung
Chien, Kuo-Liong
author_facet Ho, Li-Ting
Serafico, Bess Ma. Fabinal
Hsu, Ching-En
Chen, Zhao-Wei
Lin, Tse-Yu
Lin, Chen
Lin, Lian-Yu
Lo, Men-Tzung
Chien, Kuo-Liong
author_sort Ho, Li-Ting
collection PubMed
description Quantitative EEG (qEEG) delineates complex brain activities. Global field synchronization (GFS) is one multichannel EEG analysis that measures global functional connectivity through quantification of synchronization between signals. We hypothesized that preservation of global functional connectivity of brain activity might be a surrogate marker for good outcome in sudden cardiac arrest (SCA) survivors. In addition, we examined the relation of phase coherence and GFS in a mathematical approach. We retrospectively collected EEG data of SCA survivors in one academic medical center. We included 75 comatose patients who were resuscitated following in-hospital or out-of-hospital nontraumatic cardiac arrest between 2013 and 2017 in the intensive care unit (ICU) of National Taiwan University Hospital (NTUH). Twelve patients (16%) were defined as good outcome (GO) (CPC 1–2). The mean age in the GO group was low (51.6 ± 15.7 vs. 68.1 ± 12.9, p < 0.001). We analyzed standard EEG power, computed EEG GFS, and assessed the cerebral performance category (CPC) score 3 months after discharge. The alpha band showed the highest discrimination ability (area under curve [AUC] = 0.78) to predict GO using power. The alpha band of GFS showed the highest AUC value (0.8) to predict GO in GFS. Furthermore, by combining EEG power + GFS, the alpha band showed the best prediction value (AUC 0.86) in predicting GO. The sensitivity of EEG power + GFS was 73%, specificity was 93%, PPV was 0.67%, and NPV was 0.94%. In conclusion, by combining GFS and EEG power analysis, the neurological outcome of the nontraumatic cardiac arrest survivor can be well-predicted. Furthermore, we proved from a mathematical point of view that although both amplitude and phase contribute to obtaining GFS, the interference in phase variation drastically changes the possibility of generating a good GFS score.
format Online
Article
Text
id pubmed-9065675
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-90656752022-05-04 Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors Ho, Li-Ting Serafico, Bess Ma. Fabinal Hsu, Ching-En Chen, Zhao-Wei Lin, Tse-Yu Lin, Chen Lin, Lian-Yu Lo, Men-Tzung Chien, Kuo-Liong Front Physiol Physiology Quantitative EEG (qEEG) delineates complex brain activities. Global field synchronization (GFS) is one multichannel EEG analysis that measures global functional connectivity through quantification of synchronization between signals. We hypothesized that preservation of global functional connectivity of brain activity might be a surrogate marker for good outcome in sudden cardiac arrest (SCA) survivors. In addition, we examined the relation of phase coherence and GFS in a mathematical approach. We retrospectively collected EEG data of SCA survivors in one academic medical center. We included 75 comatose patients who were resuscitated following in-hospital or out-of-hospital nontraumatic cardiac arrest between 2013 and 2017 in the intensive care unit (ICU) of National Taiwan University Hospital (NTUH). Twelve patients (16%) were defined as good outcome (GO) (CPC 1–2). The mean age in the GO group was low (51.6 ± 15.7 vs. 68.1 ± 12.9, p < 0.001). We analyzed standard EEG power, computed EEG GFS, and assessed the cerebral performance category (CPC) score 3 months after discharge. The alpha band showed the highest discrimination ability (area under curve [AUC] = 0.78) to predict GO using power. The alpha band of GFS showed the highest AUC value (0.8) to predict GO in GFS. Furthermore, by combining EEG power + GFS, the alpha band showed the best prediction value (AUC 0.86) in predicting GO. The sensitivity of EEG power + GFS was 73%, specificity was 93%, PPV was 0.67%, and NPV was 0.94%. In conclusion, by combining GFS and EEG power analysis, the neurological outcome of the nontraumatic cardiac arrest survivor can be well-predicted. Furthermore, we proved from a mathematical point of view that although both amplitude and phase contribute to obtaining GFS, the interference in phase variation drastically changes the possibility of generating a good GFS score. Frontiers Media S.A. 2022-04-20 /pmc/articles/PMC9065675/ /pubmed/35514330 http://dx.doi.org/10.3389/fphys.2022.866844 Text en Copyright © 2022 Ho, Serafico, Hsu, Chen, Lin, Lin, Lin, Lo and Chien. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ho, Li-Ting
Serafico, Bess Ma. Fabinal
Hsu, Ching-En
Chen, Zhao-Wei
Lin, Tse-Yu
Lin, Chen
Lin, Lian-Yu
Lo, Men-Tzung
Chien, Kuo-Liong
Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors
title Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors
title_full Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors
title_fullStr Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors
title_full_unstemmed Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors
title_short Preserved Electroencephalogram Power and Global Synchronization Predict Better Neurological Outcome in Sudden Cardiac Arrest Survivors
title_sort preserved electroencephalogram power and global synchronization predict better neurological outcome in sudden cardiac arrest survivors
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065675/
https://www.ncbi.nlm.nih.gov/pubmed/35514330
http://dx.doi.org/10.3389/fphys.2022.866844
work_keys_str_mv AT holiting preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors
AT seraficobessmafabinal preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors
AT hsuchingen preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors
AT chenzhaowei preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors
AT lintseyu preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors
AT linchen preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors
AT linlianyu preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors
AT lomentzung preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors
AT chienkuoliong preservedelectroencephalogrampowerandglobalsynchronizationpredictbetterneurologicaloutcomeinsuddencardiacarrestsurvivors