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Dynamics of novel COVID-19 in the presence of Co-morbidity

A novel coronavirus (COVID-19) has emerged as a global serious public health issue from December 2019. People having a weak immune system are more susceptible to coronavirus infection. It is a double challenge for people of any age with certain underlying medical conditions including cardiovascular...

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Autores principales: Saha, Amit Kumar, Podder, Chandra Nath, Niger, Ashrafi Meher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065686/
https://www.ncbi.nlm.nih.gov/pubmed/35530528
http://dx.doi.org/10.1016/j.idm.2022.04.005
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author Saha, Amit Kumar
Podder, Chandra Nath
Niger, Ashrafi Meher
author_facet Saha, Amit Kumar
Podder, Chandra Nath
Niger, Ashrafi Meher
author_sort Saha, Amit Kumar
collection PubMed
description A novel coronavirus (COVID-19) has emerged as a global serious public health issue from December 2019. People having a weak immune system are more susceptible to coronavirus infection. It is a double challenge for people of any age with certain underlying medical conditions including cardiovascular disease, diabetes, high blood pressure and cancer etc. Co-morbidity increases the probability of COVID-19 complication. In this paper a deterministic compartmental model is formulated to understand the transmission dynamics of COVID-19. Rigorous mathematical analysis of the model shows that it exhibits backward bifurcation phenomenon when the basic reproduction number is less than unity. For the case of no re-infection it is shown that having the reproduction number less than one is necessary and sufficient for the effective control of COVID-19, that is, the disease free equilibrium is globally asymptotically stable when the reproduction threshold is less than unity. Furthermore, in the absence of reinfection, a unique endemic equilibrium of the model exists which is globally asymptotically stable whenever the reproduction number is greater than unity. Numerical simulations of the model, using data relevant to COVID-19 transmission dynamics, show that the use of efficacious face masks publicly could lead to the elimination of COVID-19 up to a satisfactory level. The study also shows that in the presence of co-morbidity, the disease increases significantly.
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spelling pubmed-90656862022-05-04 Dynamics of novel COVID-19 in the presence of Co-morbidity Saha, Amit Kumar Podder, Chandra Nath Niger, Ashrafi Meher Infect Dis Model Original Research Article A novel coronavirus (COVID-19) has emerged as a global serious public health issue from December 2019. People having a weak immune system are more susceptible to coronavirus infection. It is a double challenge for people of any age with certain underlying medical conditions including cardiovascular disease, diabetes, high blood pressure and cancer etc. Co-morbidity increases the probability of COVID-19 complication. In this paper a deterministic compartmental model is formulated to understand the transmission dynamics of COVID-19. Rigorous mathematical analysis of the model shows that it exhibits backward bifurcation phenomenon when the basic reproduction number is less than unity. For the case of no re-infection it is shown that having the reproduction number less than one is necessary and sufficient for the effective control of COVID-19, that is, the disease free equilibrium is globally asymptotically stable when the reproduction threshold is less than unity. Furthermore, in the absence of reinfection, a unique endemic equilibrium of the model exists which is globally asymptotically stable whenever the reproduction number is greater than unity. Numerical simulations of the model, using data relevant to COVID-19 transmission dynamics, show that the use of efficacious face masks publicly could lead to the elimination of COVID-19 up to a satisfactory level. The study also shows that in the presence of co-morbidity, the disease increases significantly. KeAi Publishing 2022-05-04 /pmc/articles/PMC9065686/ /pubmed/35530528 http://dx.doi.org/10.1016/j.idm.2022.04.005 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Saha, Amit Kumar
Podder, Chandra Nath
Niger, Ashrafi Meher
Dynamics of novel COVID-19 in the presence of Co-morbidity
title Dynamics of novel COVID-19 in the presence of Co-morbidity
title_full Dynamics of novel COVID-19 in the presence of Co-morbidity
title_fullStr Dynamics of novel COVID-19 in the presence of Co-morbidity
title_full_unstemmed Dynamics of novel COVID-19 in the presence of Co-morbidity
title_short Dynamics of novel COVID-19 in the presence of Co-morbidity
title_sort dynamics of novel covid-19 in the presence of co-morbidity
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065686/
https://www.ncbi.nlm.nih.gov/pubmed/35530528
http://dx.doi.org/10.1016/j.idm.2022.04.005
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