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Additional data for the mouse TRPV6 expression atlas

To identify TRPV6 expression in the whole mouse with a cellular resolution we took advantage of TRPV6-IRES-Cre knock-in mice crossed with the enhanced ROSA26-τGFP reporter line. In the resulting TRPV6-IC/eR26-τGFP animals, TRPV6-expressing cells are labeled with τGFP. Data were collected from organs...

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Autores principales: Wartenberg, Philipp, Lux, Femke, Busch, Kai, Fecher-Trost, Claudia, Flockerzi, Veit, Krasteva-Christ, Gabriela, Boehm, Ulrich, Weissgerber, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065733/
https://www.ncbi.nlm.nih.gov/pubmed/35516004
http://dx.doi.org/10.1016/j.dib.2022.108201
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author Wartenberg, Philipp
Lux, Femke
Busch, Kai
Fecher-Trost, Claudia
Flockerzi, Veit
Krasteva-Christ, Gabriela
Boehm, Ulrich
Weissgerber, Petra
author_facet Wartenberg, Philipp
Lux, Femke
Busch, Kai
Fecher-Trost, Claudia
Flockerzi, Veit
Krasteva-Christ, Gabriela
Boehm, Ulrich
Weissgerber, Petra
author_sort Wartenberg, Philipp
collection PubMed
description To identify TRPV6 expression in the whole mouse with a cellular resolution we took advantage of TRPV6-IRES-Cre knock-in mice crossed with the enhanced ROSA26-τGFP reporter line. In the resulting TRPV6-IC/eR26-τGFP animals, TRPV6-expressing cells are labeled with τGFP. Data were collected from organs prepared from fixed experimental adult and juvenile TRPV6-IC/eR26τGFP and Cre-negative eR26-τGFP control animals of both sexes. Organ cryosections from each age and sex were stained for GFP and imaged with a slide scanner. Here, we describe reporter gene expression in a large number of tissues. We also document the absence of τGFP signal in the corresponding Cre-negative control tissues, including controls for the TRPV6 expression data described in [1]. The data reported here and in [1] constitute the TRPV6 expression atlas for the mouse. Our data offer a wealth of information to enable investigation of the functional role of TRPV6 channels in different tissues.
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spelling pubmed-90657332022-05-04 Additional data for the mouse TRPV6 expression atlas Wartenberg, Philipp Lux, Femke Busch, Kai Fecher-Trost, Claudia Flockerzi, Veit Krasteva-Christ, Gabriela Boehm, Ulrich Weissgerber, Petra Data Brief Data Article To identify TRPV6 expression in the whole mouse with a cellular resolution we took advantage of TRPV6-IRES-Cre knock-in mice crossed with the enhanced ROSA26-τGFP reporter line. In the resulting TRPV6-IC/eR26-τGFP animals, TRPV6-expressing cells are labeled with τGFP. Data were collected from organs prepared from fixed experimental adult and juvenile TRPV6-IC/eR26τGFP and Cre-negative eR26-τGFP control animals of both sexes. Organ cryosections from each age and sex were stained for GFP and imaged with a slide scanner. Here, we describe reporter gene expression in a large number of tissues. We also document the absence of τGFP signal in the corresponding Cre-negative control tissues, including controls for the TRPV6 expression data described in [1]. The data reported here and in [1] constitute the TRPV6 expression atlas for the mouse. Our data offer a wealth of information to enable investigation of the functional role of TRPV6 channels in different tissues. Elsevier 2022-04-22 /pmc/articles/PMC9065733/ /pubmed/35516004 http://dx.doi.org/10.1016/j.dib.2022.108201 Text en © 2022 The Author(s). Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Wartenberg, Philipp
Lux, Femke
Busch, Kai
Fecher-Trost, Claudia
Flockerzi, Veit
Krasteva-Christ, Gabriela
Boehm, Ulrich
Weissgerber, Petra
Additional data for the mouse TRPV6 expression atlas
title Additional data for the mouse TRPV6 expression atlas
title_full Additional data for the mouse TRPV6 expression atlas
title_fullStr Additional data for the mouse TRPV6 expression atlas
title_full_unstemmed Additional data for the mouse TRPV6 expression atlas
title_short Additional data for the mouse TRPV6 expression atlas
title_sort additional data for the mouse trpv6 expression atlas
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065733/
https://www.ncbi.nlm.nih.gov/pubmed/35516004
http://dx.doi.org/10.1016/j.dib.2022.108201
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