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Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration

Immune checkpoint inhibitors (ICIs) have become a new hope for many patients with advanced cancer by blocking tumour immune evasion. However, with the widespread use of ICIs, immune‐related adverse events (irAEs) have also been discovered and reported increasingly. Immune‐related myocarditis, the mo...

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Autores principales: Liu, Zhijie, Fan, Yiming, Guo, Jun, Bian, Ning, Chen, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065848/
https://www.ncbi.nlm.nih.gov/pubmed/35322589
http://dx.doi.org/10.1002/ehf2.13912
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author Liu, Zhijie
Fan, Yiming
Guo, Jun
Bian, Ning
Chen, Dongdong
author_facet Liu, Zhijie
Fan, Yiming
Guo, Jun
Bian, Ning
Chen, Dongdong
author_sort Liu, Zhijie
collection PubMed
description Immune checkpoint inhibitors (ICIs) have become a new hope for many patients with advanced cancer by blocking tumour immune evasion. However, with the widespread use of ICIs, immune‐related adverse events (irAEs) have also been discovered and reported increasingly. Immune‐related myocarditis, the most dangerous one of irAEs, still has high mortality in the context of the current treatment. We report the case of a 60‐year‐old female with fulminant myocarditis induced by ICIs, which caused her to experience frequent ventricular arrhythmias such as ventricular fibrillation and heart failure. She was successfully treated with current mainstream therapies for immune‐related myocarditis and additional treatment of sacubitril–valsartan and dapagliflozin. The intriguing observation that the patient condition recovered relatively rapidly in this case shows a possible treatment inspiration, which may be helpful for treating ICIs‐associated myocarditis and improving cancer patients' clinical prognosis.
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spelling pubmed-90658482022-05-04 Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration Liu, Zhijie Fan, Yiming Guo, Jun Bian, Ning Chen, Dongdong ESC Heart Fail Case Reports Immune checkpoint inhibitors (ICIs) have become a new hope for many patients with advanced cancer by blocking tumour immune evasion. However, with the widespread use of ICIs, immune‐related adverse events (irAEs) have also been discovered and reported increasingly. Immune‐related myocarditis, the most dangerous one of irAEs, still has high mortality in the context of the current treatment. We report the case of a 60‐year‐old female with fulminant myocarditis induced by ICIs, which caused her to experience frequent ventricular arrhythmias such as ventricular fibrillation and heart failure. She was successfully treated with current mainstream therapies for immune‐related myocarditis and additional treatment of sacubitril–valsartan and dapagliflozin. The intriguing observation that the patient condition recovered relatively rapidly in this case shows a possible treatment inspiration, which may be helpful for treating ICIs‐associated myocarditis and improving cancer patients' clinical prognosis. John Wiley and Sons Inc. 2022-03-23 /pmc/articles/PMC9065848/ /pubmed/35322589 http://dx.doi.org/10.1002/ehf2.13912 Text en © 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Liu, Zhijie
Fan, Yiming
Guo, Jun
Bian, Ning
Chen, Dongdong
Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration
title Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration
title_full Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration
title_fullStr Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration
title_full_unstemmed Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration
title_short Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration
title_sort fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065848/
https://www.ncbi.nlm.nih.gov/pubmed/35322589
http://dx.doi.org/10.1002/ehf2.13912
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