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Predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values

OBJECTIVE: A formula is needed that is practical for current livestock breeding methods and that predicts the approximate rate of inbreeding (ΔF) in populations where selection is performed according to four-path programs (sires to breed sons, sires to breed daughters, dams to breed sons, and dams t...

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Autores principales: Togashi, Kenji, Adachi, Kazunori, Kurogi, Kazuhito, Yasumori, Takanori, Watanabe, Toshio, Toda, Shohei, Matsubara, Satoshi, Hirohama, Kiyohide, Takahashi, Tsutomu, Matsuo, Shoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Animal Bioscience 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066037/
https://www.ncbi.nlm.nih.gov/pubmed/34991226
http://dx.doi.org/10.5713/ab.21.0350
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author Togashi, Kenji
Adachi, Kazunori
Kurogi, Kazuhito
Yasumori, Takanori
Watanabe, Toshio
Toda, Shohei
Matsubara, Satoshi
Hirohama, Kiyohide
Takahashi, Tsutomu
Matsuo, Shoichi
author_facet Togashi, Kenji
Adachi, Kazunori
Kurogi, Kazuhito
Yasumori, Takanori
Watanabe, Toshio
Toda, Shohei
Matsubara, Satoshi
Hirohama, Kiyohide
Takahashi, Tsutomu
Matsuo, Shoichi
author_sort Togashi, Kenji
collection PubMed
description OBJECTIVE: A formula is needed that is practical for current livestock breeding methods and that predicts the approximate rate of inbreeding (ΔF) in populations where selection is performed according to four-path programs (sires to breed sons, sires to breed daughters, dams to breed sons, and dams to breed daughters). The formula widely used to predict inbreeding neglects selection, we need to develop a new formula that can be applied with or without selection. METHODS: The core of the prediction is to incorporate the long-tern genetic influence of the selected parents in four-selection paths executed as sires to breed sons, sires to breed daughters, dams to breed sons, and dams to breed daughters. The rate of inbreeding was computed as the magnitude that is proportional to the sum of squared long-term genetic contributions of the parents of four-selection paths to the selected offspring. RESULTS: We developed a formula to predict the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values and with discrete generations. The new formula can be applied with or without selection. Neglecting the effects of selection led to underestimation of the rate of inbreeding by 40% to 45%. CONCLUSION: The formula we developed here would be highly useful as a practical method for predicting the approximate rate of inbreeding (ΔF) in populations where selection is performed according to four-path programs.
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spelling pubmed-90660372022-06-01 Predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values Togashi, Kenji Adachi, Kazunori Kurogi, Kazuhito Yasumori, Takanori Watanabe, Toshio Toda, Shohei Matsubara, Satoshi Hirohama, Kiyohide Takahashi, Tsutomu Matsuo, Shoichi Anim Biosci Article OBJECTIVE: A formula is needed that is practical for current livestock breeding methods and that predicts the approximate rate of inbreeding (ΔF) in populations where selection is performed according to four-path programs (sires to breed sons, sires to breed daughters, dams to breed sons, and dams to breed daughters). The formula widely used to predict inbreeding neglects selection, we need to develop a new formula that can be applied with or without selection. METHODS: The core of the prediction is to incorporate the long-tern genetic influence of the selected parents in four-selection paths executed as sires to breed sons, sires to breed daughters, dams to breed sons, and dams to breed daughters. The rate of inbreeding was computed as the magnitude that is proportional to the sum of squared long-term genetic contributions of the parents of four-selection paths to the selected offspring. RESULTS: We developed a formula to predict the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values and with discrete generations. The new formula can be applied with or without selection. Neglecting the effects of selection led to underestimation of the rate of inbreeding by 40% to 45%. CONCLUSION: The formula we developed here would be highly useful as a practical method for predicting the approximate rate of inbreeding (ΔF) in populations where selection is performed according to four-path programs. Animal Bioscience 2022-06 2022-01-03 /pmc/articles/PMC9066037/ /pubmed/34991226 http://dx.doi.org/10.5713/ab.21.0350 Text en Copyright © 2022 by Animal Bioscience https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Togashi, Kenji
Adachi, Kazunori
Kurogi, Kazuhito
Yasumori, Takanori
Watanabe, Toshio
Toda, Shohei
Matsubara, Satoshi
Hirohama, Kiyohide
Takahashi, Tsutomu
Matsuo, Shoichi
Predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values
title Predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values
title_full Predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values
title_fullStr Predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values
title_full_unstemmed Predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values
title_short Predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values
title_sort predicting the rate of inbreeding in populations undergoing four-path selection on genomically enhanced breeding values
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066037/
https://www.ncbi.nlm.nih.gov/pubmed/34991226
http://dx.doi.org/10.5713/ab.21.0350
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