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RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity
Plant immune responses must be tightly controlled for proper allocation of resources for growth and development. In plants, endogenous signaling peptides regulate developmental and growth‐related processes. Recent research indicates that some of these peptides also have regulatory functions in the c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066070/ https://www.ncbi.nlm.nih.gov/pubmed/35229426 http://dx.doi.org/10.15252/embr.202153281 |
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author | Stegmann, Martin Zecua‐Ramirez, Patricia Ludwig, Christina Lee, Ho‐Seok Peterson, Brenda Nimchuk, Zachary L Belkhadir, Youssef Hückelhoven, Ralph |
author_facet | Stegmann, Martin Zecua‐Ramirez, Patricia Ludwig, Christina Lee, Ho‐Seok Peterson, Brenda Nimchuk, Zachary L Belkhadir, Youssef Hückelhoven, Ralph |
author_sort | Stegmann, Martin |
collection | PubMed |
description | Plant immune responses must be tightly controlled for proper allocation of resources for growth and development. In plants, endogenous signaling peptides regulate developmental and growth‐related processes. Recent research indicates that some of these peptides also have regulatory functions in the control of plant immune responses. This classifies these peptides as phytocytokines as they show analogies with metazoan cytokines. However, the mechanistic basis for phytocytokine‐mediated regulation of plant immunity remains largely elusive. Here, we identify GOLVEN2 (GLV2) peptides as phytocytokines in Arabidopsis thaliana. GLV2 signaling enhances sensitivity of plants to elicitation with immunogenic bacterial elicitors and contributes to resistance against virulent bacterial pathogens. GLV2 is perceived by ROOT MERISTEM GROWTH FACTOR 1 INSENSITIVE (RGI) receptors. RGI mutants show reduced elicitor sensitivity and enhanced susceptibility to bacterial infection. RGI3 forms ligand‐induced complexes with the pattern recognition receptor (PRR) FLAGELLIN SENSITIVE 2 (FLS2), suggesting that RGIs are part of PRR signaling platforms. GLV2‐RGI signaling promotes PRR abundance independent of transcriptional regulation and controls plant immunity via a previously undescribed mechanism of phytocytokine activity. |
format | Online Article Text |
id | pubmed-9066070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90660702022-05-04 RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity Stegmann, Martin Zecua‐Ramirez, Patricia Ludwig, Christina Lee, Ho‐Seok Peterson, Brenda Nimchuk, Zachary L Belkhadir, Youssef Hückelhoven, Ralph EMBO Rep Articles Plant immune responses must be tightly controlled for proper allocation of resources for growth and development. In plants, endogenous signaling peptides regulate developmental and growth‐related processes. Recent research indicates that some of these peptides also have regulatory functions in the control of plant immune responses. This classifies these peptides as phytocytokines as they show analogies with metazoan cytokines. However, the mechanistic basis for phytocytokine‐mediated regulation of plant immunity remains largely elusive. Here, we identify GOLVEN2 (GLV2) peptides as phytocytokines in Arabidopsis thaliana. GLV2 signaling enhances sensitivity of plants to elicitation with immunogenic bacterial elicitors and contributes to resistance against virulent bacterial pathogens. GLV2 is perceived by ROOT MERISTEM GROWTH FACTOR 1 INSENSITIVE (RGI) receptors. RGI mutants show reduced elicitor sensitivity and enhanced susceptibility to bacterial infection. RGI3 forms ligand‐induced complexes with the pattern recognition receptor (PRR) FLAGELLIN SENSITIVE 2 (FLS2), suggesting that RGIs are part of PRR signaling platforms. GLV2‐RGI signaling promotes PRR abundance independent of transcriptional regulation and controls plant immunity via a previously undescribed mechanism of phytocytokine activity. John Wiley and Sons Inc. 2022-03-01 /pmc/articles/PMC9066070/ /pubmed/35229426 http://dx.doi.org/10.15252/embr.202153281 Text en © 2022 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Stegmann, Martin Zecua‐Ramirez, Patricia Ludwig, Christina Lee, Ho‐Seok Peterson, Brenda Nimchuk, Zachary L Belkhadir, Youssef Hückelhoven, Ralph RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity |
title | RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity |
title_full | RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity |
title_fullStr | RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity |
title_full_unstemmed | RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity |
title_short | RGI‐GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity |
title_sort | rgi‐golven signaling promotes cell surface immune receptor abundance to regulate plant immunity |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066070/ https://www.ncbi.nlm.nih.gov/pubmed/35229426 http://dx.doi.org/10.15252/embr.202153281 |
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