Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)

INTRODUCTION: It is unknown if a temporary break in long-term immune-suppressive treatment after vaccination against COVID-19 improves vaccine response. The objective of this study was to evaluate if a 2-week interruption in low-dose weekly methotrexate treatment after SARS-CoV-2 vaccine boosters en...

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Detalles Bibliográficos
Autores principales: Abhishek, Abhishek, Boyton, RJ, McKnight, Áine, Coates, Laura, Bluett, James, Barber, Vicki S, Cureton, Lucy, Francis, Anne, Appelbe, Duncan, Eldridge, Lucy, Julier, Patrick, Peckham, Nicholas, Valdes, Ana M, Rombach, Ines, Altmann, Daniel M, Nguyen-Van-Tam, Jonathan, Williams, Hywel C, Cook, Jonathan Alistair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Rheumatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066090/
https://www.ncbi.nlm.nih.gov/pubmed/35504634
http://dx.doi.org/10.1136/bmjopen-2022-062599

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