Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors

The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-...

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Detalles Bibliográficos
Autores principales: Esposito, Anna, De Gregorio, Eliana, De Fenza, Maria, D'Alonzo, Daniele, Satawani, Anil, Guaragna, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066171/
https://www.ncbi.nlm.nih.gov/pubmed/35521350
http://dx.doi.org/10.1039/c9ra03673c
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author Esposito, Anna
De Gregorio, Eliana
De Fenza, Maria
D'Alonzo, Daniele
Satawani, Anil
Guaragna, Annalisa
author_facet Esposito, Anna
De Gregorio, Eliana
De Fenza, Maria
D'Alonzo, Daniele
Satawani, Anil
Guaragna, Annalisa
author_sort Esposito, Anna
collection PubMed
description The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-negative and -positive bacteria.
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spelling pubmed-90661712022-05-04 Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors Esposito, Anna De Gregorio, Eliana De Fenza, Maria D'Alonzo, Daniele Satawani, Anil Guaragna, Annalisa RSC Adv Chemistry The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-negative and -positive bacteria. The Royal Society of Chemistry 2019-07-10 /pmc/articles/PMC9066171/ /pubmed/35521350 http://dx.doi.org/10.1039/c9ra03673c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Esposito, Anna
De Gregorio, Eliana
De Fenza, Maria
D'Alonzo, Daniele
Satawani, Anil
Guaragna, Annalisa
Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
title Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
title_full Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
title_fullStr Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
title_full_unstemmed Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
title_short Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
title_sort expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066171/
https://www.ncbi.nlm.nih.gov/pubmed/35521350
http://dx.doi.org/10.1039/c9ra03673c
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