Arsenic trioxide induces proteasome dependent TBLR1-RARα degradation to improve leukemia eradication through cell differentiation enhancement

Background: Acute promyelocytic leukemia (APL) mainly harbors PML-RARα fusion gene, which is sensitive to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) treatment. However, APL harboring other RARα fusion genes exhibit different drug sensitivity. Here, we investigated the role and mechani...

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Detalles Bibliográficos
Autores principales: Chen, Yirui, Li, Manning, Wu, Han, Yuan, Shijin, Xia, Yan, Wang, Yingjian, Peng, Ye, Lan, Jianping, Wang, Yanzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066217/
https://www.ncbi.nlm.nih.gov/pubmed/35517404
http://dx.doi.org/10.7150/jca.66175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066217/
https://www.ncbi.nlm.nih.gov/pubmed/35517404
http://dx.doi.org/10.7150/jca.66175

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