Cargando…

Arsenic trioxide induces proteasome dependent TBLR1-RARα degradation to improve leukemia eradication through cell differentiation enhancement

Background: Acute promyelocytic leukemia (APL) mainly harbors PML-RARα fusion gene, which is sensitive to all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) treatment. However, APL harboring other RARα fusion genes exhibit different drug sensitivity. Here, we investigated the role and mechani...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yirui, Li, Manning, Wu, Han, Yuan, Shijin, Xia, Yan, Wang, Yingjian, Peng, Ye, Lan, Jianping, Wang, Yanzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066217/ https://www.ncbi.nlm.nih.gov/pubmed/35517404 http://dx.doi.org/10.7150/jca.66175

Ejemplares similares

A novel fusion protein TBLR1-RARα acts as an oncogene to induce murine promyelocytic leukemia: identification and treatment strategies
por: Li, Shouyun, et al.
Publicado: (2021)

Rationale and efficacy of proteasome inhibitor combined with arsenic trioxide in the treatment of acute promyelocytic leukemia
por: Ganesan, S, et al.
Publicado: (2016)

Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells
por: Shao, Xuejing, et al.
Publicado: (2022)

A Review of Arsenic Trioxide and Acute Promyelocytic Leukemia
por: Alimoghaddam, Kamran
Publicado: (2014)

On arsenic trioxide in the clinical treatment of acute promyelocytic leukemia
por: Zhang, Peng
Publicado: (2017)

Arsenic speciation in saliva of acute promyelocytic leukemia patients undergoing arsenic trioxide treatment
por: Chen, Baowei, et al.
Publicado: (2013)

Treatment of Acute Promyelocytic Leukemia with Single-Agent Arsenic Trioxide
por: Mathews, Vikram, et al.
Publicado: (2011)

Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin
por: Hu, Xuqiao, et al.
Publicado: (2021)

Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation
por: Wang, Qian Qian, et al.
Publicado: (2015)

Importance of monitoring arsenic methylation metabolism in acute promyelocytic leukemia patients receiving the treatment of arsenic trioxide
por: Zheng, Yu, et al.
Publicado: (2021)

Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells
por: Zeng, Yingjian, et al.
Publicado: (2016)

Metabolic adaptation drives arsenic trioxide resistance in acute promyelocytic leukemia
por: Balasundaram, Nithya, et al.
Publicado: (2022)

Arsenic trioxide for acute promyelocytic leukemia in a patient on chronic hemodialysis
por: Tinajero, Jose, et al.
Publicado: (2022)

TBLR1 regulates the expression of nuclear hormone receptor co-repressors
por: Zhang, Xin-Min, et al.
Publicado: (2006)

Role of Signal Regulatory Protein α in Arsenic Trioxide-induced Promyelocytic Leukemia Cell Apoptosis
por: Pan, Chaoyun, et al.
Publicado: (2016)

hsa-miR-203 enhances the sensitivity of leukemia cells to arsenic trioxide
por: HE, JIN-HUA, et al.
Publicado: (2013)

Pyrrolidine Dithiocarbamate Facilitates Arsenic Trioxide Against Pancreatic Cancer via Perturbing Ubiquitin-Proteasome Pathway
por: Yu, Simin, et al.
Publicado: (2020)

Catechins induced acute promyelocytic leukemia cell apoptosis and triggered PML-RARα oncoprotein degradation
por: Zhang, Li, et al.
Publicado: (2014)

MicroRNA-204 Potentiates the Sensitivity of Acute Myeloid Leukemia Cells to Arsenic Trioxide
por: Wang, Zhiguo, et al.
Publicado: (2019)

Arsenic trioxide induces depolymerization of microtubules in an acute promyelocytic leukemia cell line
por: Baek, Jin Ho, et al.
Publicado: (2012)

Feasibility of oral arsenic trioxide treatment for acute promyelocytic leukemia during hemodialysis
por: Au, Wing-Yan, et al.
Publicado: (2012)

Arsenic Trioxide and Resveratrol Show Synergistic Anti-Leukemia Activity and Neutralized Cardiotoxicity
por: Fan, Yuhua, et al.
Publicado: (2014)

Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives
por: McCulloch, Derek, et al.
Publicado: (2017)

Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9
por: Chau, David, et al.
Publicado: (2015)

Arsenic trioxide induces autophagic degradation of the FLT3-ITD mutated protein in FLT3-ITD acute myeloid leukemia cells
por: Liu, Xiao-Jian, et al.
Publicado: (2020)

Arsenic trioxide promoting ETosis in acute promyelocytic leukemia through mTOR-regulated autophagy
por: Li, Tao, et al.
Publicado: (2018)

TBLR1 is a novel prognostic marker and promotes epithelial–mesenchymal transition in cervical cancer
por: Wang, J, et al.
Publicado: (2014)

Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides
por: Beez, Sabine, et al.
Publicado: (2012)

Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase
por: Yan, Wensheng, et al.
Publicado: (2014)

USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1
por: Li, Yuancheng, et al.
Publicado: (2020)

Ascorbic Acid Potentiation of Arsenic Trioxide Anticancer Activity Against Acute Promyelocytic Leukemia
por: Yedjou, Clement, et al.
Publicado: (2009)

Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress
por: Masciarelli, S, et al.
Publicado: (2018)

Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives [Corrigendum]
Publicado: (2017)

Synergy between parthenolide and arsenic trioxide in adult T-cell leukemia/lymphoma cells in vitro
por: Kouhpaikar, Hamideh, et al.
Publicado: (2020)

Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: A Systematic Review
por: Mohammadi Kanesbi, Mehdi, et al.
Publicado: (2020)

Successful treatment of acute promyelocytic leukemia in a patient under hemodialysis with arsenic trioxide
por: Hashimoto, Akiko, et al.
Publicado: (2021)

Successful treatment of acute promyelocytic leukemia in a patient undergoing hemodialysis with arsenic trioxide
por: Hashimoto, Akiko, et al.
Publicado: (2021)

Effect of additional cytogenetic abnormalities on survival in arsenic trioxide-treated acute promyelocytic leukemia
por: Epstein-Peterson, Zachary D., et al.
Publicado: (2022)

Evidences of Protective Potentials of Microdoses of Ultra-High Diluted Arsenic Trioxide in Mice Receiving Repeated Injections of Arsenic Trioxide
por: Banerjee, Pathikrit, et al.
Publicado: (2011)

Tetraarsenictetrasulfide and Arsenic Trioxide Exert Synergistic Effects on Induction of Apoptosis and Differentiation in Acute Promyelocytic Leukemia Cells
por: Wang, Shuping, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ajfk4mf4u3eussk9p4crc2su68