TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans

Although amyloid β (Aβ) and tau aggregates define the neuropathology of Alzheimer's disease (AD), TDP-43 has recently emerged as a co-morbid pathology in more than half of patients with AD. Individuals with concomitant Aβ, tau and TDP-43 pathology experience accelerated cognitive decline and wo...

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Detalles Bibliográficos
Autores principales: Latimer, Caitlin S., Stair, Jade G., Hincks, Joshua C., Currey, Heather N., Bird, Thomas D., Keene, C. Dirk, Kraemer, Brian C., Liachko, Nicole F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066518/
https://www.ncbi.nlm.nih.gov/pubmed/35178571
http://dx.doi.org/10.1242/dmm.049323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066518/
https://www.ncbi.nlm.nih.gov/pubmed/35178571
http://dx.doi.org/10.1242/dmm.049323

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